14 products were found matching "SYN-1177-M100"!

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SB-590885
SB-590885

Item number: SYN-1077-M100

Soluble in DMSO or ethanol. SB-590885 is a novel, potent and selective small molecule inhibitor of B-Raf kinase, with a Ki of 0.16nM. It shows an 11-fold greater selectivity for B-Raf over c-Raf. It was used to address the dependence of MAPK signalling and tumor cell growth on B-Raf kinase activity. Target: ARaf -...
Keywords: SB-590885
Application: BRAF inhibitor
CAS 405554-55-4
MW: 453,5 D
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XL-765
XL-765

Item number: SYN-1137-M100

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. XL765 is active against class I PI3K (IC(50) = 39, 113, 9 and 43nM for p110alpha, beta, gamma and delta, respectively). XL765 also inhibits DNA-PK (IC(50) = 150nM) and mTOR (IC(50) = 157nM. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid
Keywords: SAR-245409
Application: PI3K / DNA-PK / mTOR inhibitor
CAS 1349796-36-6
MW: 599,7 D
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MLN-0128
MLN-0128

Item number: SYN-1157-M100

Soluble in DMSO or ethanol. MLN0128 is a potent and selective mTOR inhibitor with an IC(50) of 1nM, >200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes (vs Rapamycin).
Keywords: MLN-0128, INK-128
Application: mTOR inhibitor
CAS 1224844-38-5
MW: 309,3 D
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SCH-900776
SCH-900776

Item number: SYN-1173-M100

Soluble in DMSO or ethanol. SCH900776 is a selective Chk1 inhibitor with an IC(50) of 3nM. It shows 50-fold selectivity for Chk1 versus Chk2. Target: Chk1 , Kinase Group: CAMK , Substrate: Serine-Threonine
Keywords: MK-8776
Application: Chk1 inhibitor
CAS 891494-63-6
MW: 376,3 D
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Bafetinib
Bafetinib

Item number: SYN-1179-M100

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. Bafetinib (INNO-406) is a potent and selective dual Bcr-Abl, Lyn inhibitor with IC(50) values of 5.8nM and 19nM, respectively.
Keywords: NS-187, INNO-406
Application: Bcr-Abl / Lyn inhibitor
CAS 859212-16-1
MW: 576,6 D
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GSK-1120212
GSK-1120212

Item number: SYN-1170-M100

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. GSK1120212 (JTP-74057, trametinib) is a highly specific and potent MEK1 and MEK2 inhibitor with IC(50) values of 0.92nM and 1.8nM respectively. Target: MEK1 - MEK2 , Kinase Group: STE , Substrate: Serine-Threonine
Keywords: JTP-74057, GSK212, Trametinib
Application: MEK1 / MEK2 inhibitor
CAS 871700-17-3
MW: 615,4 D
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IPI-145
IPI-145

Item number: SYN-1175-M100

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. IPI-145 is a potent, oral inhibitor of Class I phosphoinositide-3-kinase (PI3K)-delta and PI3K-gamma (IC(50) of 243 pM and 50nM), and is clinically active in patients with advanced hematological malignancies. Target: PI3K , Kinase Group: Atypical (PIKK) ,...
Keywords: IPI 145
Application: PI3K gamma / delta inhibitor
CAS 1201438-56-3
MW: 416,9 D
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MPI-0479605
MPI-0479605

Item number: SYN-1187-M100

Soluble in DMSO. MPI-0479605 inhibits TTK kinase activity in vitro with an IC(50) of 4nM.
Keywords: MPI0479605
Application: TTK inhibitor
CAS 1246529-32-7
MW: 444,0 D
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BLZ-945
BLZ-945

Item number: SYN-1197-M100

Soluble in DMSO. BLZ945 is an orally active, potent and selective CSF-1R inhibitor, which inhibits CSF-1R activity with an IC(50) of 1nM and is more than 1000-fold selective against its closest receptor tyrosine kinase homologs c-KIT and Platelet-derived Growth Factor Receptor beta (PDGFRbeta ) as well as more than...
Keywords: BLZ945
Application: CSF1R / c-FMS inhibitor
CAS 953769-46-5
MW: 398,5 D
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TG-89
TG-89

Item number: SYN-1107-M100

Soluble in DMSO or ethanol. TG-89 is a JAK inhibitor. It has IC(50) values of 6, 25, 17 and 169nM against JAK2, FLT3, RET and JAK3 respectively. Target: JAK2 , Kinase Group: PTK , Substrate: Tyrosine
Keywords: TG89
Application: JAK2 / FLT3 / RET / JAK3 inhibitor
CAS 936091-56-4
MW: 510,7 D
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Bentamapimod
Bentamapimod

Item number: SYN-1147-M100

Soluble in DMSO. Bentamapimod (AS602801) is a novel and orally active c-Jun-N-Terminal Kinase Inhibitor highly specific for JNK kinases. The inhibitor Bentamapimod (AS602801) is a potent anti-inflammatory agent which has been shown to reduce the disease burden in several pre-clinical models for endometriosis, and...
Keywords: AS-602801
Application: JNK inhibitor
CAS 848344-36-5
MW: 457,6 D
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AZD-2014
AZD-2014

Item number: SYN-1167-M100

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. AZD2014 is a dual mTORC1/mTORC2 inhibitor for the treatment of advanced solid malignancies. Target: mTOR , Kinase Group: Atypical (PIKK) , Substrate: Serine-Threonine
Keywords: AZD2014
Application: mTOR inhibitor
CAS 1009298-59-2
MW: 462,5 D
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