PDE1A Assay Kit

PDE1A Assay Kit
Item number Size Datasheet Manual SDS Delivery time Quantity Price
BPS-60310 96 rxns - -

3 - 15 business days*

599.00€
 
Phosphodiesterases (PDEs) play an important role in dynamic regulation of cAMP and cGMP... more
Product information "PDE1A Assay Kit"
Phosphodiesterases (PDEs) play an important role in dynamic regulation of cAMP and cGMP signaling. PDE1A1 is a calmodulin-dependent PDE and expressed in lung and heart. PDE1A1 is believed to regulate vascular smooth muscle contraction and may play a role in sperm function. The PDE1A Assay Kit is designed for identification of PDE1A inhibitors using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by PDE1A1 to the binding agent. The PDE1A inhibitor screening assay kit comes in a convenient 96-well format, including purified PDE1A1 enzyme, fluorescently labeled PDE1A substrate (cAMP), binding agent, and PDE assay buffer for 100 enzyme reactions. The key to the PDE1A Assay Kit is the specific binding agent. Using this kit, only two simple steps on a microtiter plate are required for PDE1A reactions. First, the fluorescently labeled cAMP is incubated with a sample containing PDE1A1 for 1 hour. Second, a binding agent is added to the reaction mix to produce a change in fluorescent polarization that can then be measured using a fluorescence reader.
Keywords: inhibitor screening, assay kit, PDE1A,
Supplier: BPS Bioscience
Supplier-Nr: 60310

Properties

Application: Enzyme kinetics, inhibitor screening, HTS
Species reactivity: human
Format: Homog.

Handling & Safety

Storage: vT
Shipping: -80°C (International: -80°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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