PD 173074

Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13032-5 5 mg -

6 - 10 business days*

53.00€
Cay13032-10 10 mg -

6 - 10 business days*

100.00€
Cay13032-25 25 mg -

6 - 10 business days*

196.00€
Cay13032-50 50 mg -

6 - 10 business days*

365.00€
 
The fibroblast growth factor receptors (FGFRs) are cell surface receptors with intrinsic tyrosine... more
Product information "PD 173074"
The fibroblast growth factor receptors (FGFRs) are cell surface receptors with intrinsic tyrosine kinase activity, which is necessary for receptor activation and signal propagation. PD 173074 is a potent and selective inhibitor of FGFR tyrosine kinase activity, blocking autophosphorylation of FGFR1 with an IC50 value of 21.5 nM. For comparison, it weakly inhibits PDGFR and c-Src (IC50 = 17.6 and 19.8 µM, respectively) and has no effect on EGFR, InsR, MEK, or PKC. PD 173074 also prevents signaling, at nanomolar levels, through FGFR2-5. Inhibition of FGFR signaling using PD 173074, impairs angiogenesis as well as self-renewal of stem cells via ERK1/2 activation.Formal Name: N-[2-[[4-(diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-urea. CAS Number: 219580-11-7. Molecular Formula: C28H41N7O3. Formula Weight: 523.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 1 mg/mL, Ethanol: 25 mg/mL. lambdamax: 238, 284, 368 nm. SMILES: CCN(CC)CCCCNc1ncc2cc(c3cc(OC)cc(OC)c3)c(NC(=O)NC(C)(C)C)nc2n1. InChi Code: InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36). InChi Key: DXCUKNQANPLTEJ-UHFFFAOYSA-N.
Keywords: N-[2-[[4-(diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-urea
Supplier: Cayman Chemical
Supplier-Nr: 13032

Properties

Application: FGFR inhibitor
MW: 523.7 D
Formula: C28H41N7O3
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 219580-11-7| Matching products
KEGG ID : K05095 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319, H335
P Phrases: P261, P264, P271, P280, P312, P321, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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