2 products were found matching "Cay13034-1"!

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Item number: Cay13034-10

The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors. PD 0325901 is a potent MEK inhibitor that suppresses phosphorylation of ERK in mouse colon 26 tumors with an IC50 value of 0.33 nM. Suppression of ERK activation...

Keywords:	N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide
Application:	MEK inhibitor
CAS	391210-10-9
MW:	482.2 D

From 58.00€ *

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SB-431542 (hydrate)

Item number: Cay13031-1

SB-431542 is a potent and selective inhibitor of the TGF-beta1 receptor ALK5 (IC50 = 94 nM). It is a less potent antagonist of ALK4 (IC50 = 140 nM) and ALK7. It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested. SB-431542 specifically blocks Smad signaling, reducing gene...

Keywords:	4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide, hydrate
Application:	ALK4 inhibitor, ALK5 inhibitor, ALK7 inhibitor
MW:	384.4 D

From 43.00€ *

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