PARP-1 [ARTD1] (E988K Mutant) (human) (rec.) Control

PARP-1 [ARTD1] (E988K Mutant) (human) (rec.) Control
%
Item number Size Datasheet Manual SDS Delivery time Quantity Discount Price
AG-40T-0015-C010 10 µg -

3 - 9 business days*

10 %
160.00€
144.00€
 
Human full-length inactive mutant E998K of PARP-1 is fused to a HA-tag and a His-tag. Liquid. In... more
Product information "PARP-1 [ARTD1] (E988K Mutant) (human) (rec.) Control"
Human full-length inactive mutant E998K of PARP-1 is fused to a HA-tag and a His-tag. Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride and 50mM imidazole, 0.2% NP-40 and 10% glycerol. PARP-1 (ARTD1) is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. PARP-1 positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. It forms a complex with EEF1A1 and TXK that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. PARP-1 (E998K mutant) is an inactive form of PARP-1 which can be used as a control compound.
Keywords: ADPRT, ARTD1, PARP1, PARP-1, ADPRT 1, EC=2.4.2.30, Poly[ADP-ribose] synthase 1, Poly [ADP-ribose] polymerase 1, NAD(+) ADP-ribosyltransferase 1, ADP-ribosyltransferase diphtheria toxin-like 1 (E998K)
Supplier: AdipoGen Life Sciences
Supplier-Nr: AG-40T-0015

Properties

Application: Negative control
Conjugate: No
Host: Insect cells
Species reactivity: human
Format: Liquid

Handling & Safety

Storage: -80°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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