8 products were found matching "Cay17340"!

Oxcarbazepine is a prodrug form of the antiepileptic compound 10,11-dihydro-10-hydroxy carbamazepine (Cay-18467). It inhibits high-frequency repetitive firing of rat spinal cord neurons when used at a concentration of 1 µM. Oxcarbazepine protects against electroshock-induced tonic hindlimb extension (ED50 = 10-20...

Midodrine is a prodrug form of the alpha1-adrenergic receptor (alpha1-AR) agonist desglymidodrine (Cay-35608). It is converted to desglymidodrine by enzymatic hydrolysis. Midodrine (5 mg/kg) increases mean arterial pressure (MAP) and decreases heart rate in normotensive rats. Formulations containing midodrine have...

Progeria is a genetic disorder that results in the appearance of premature aging. Genetically, progeria is characterized by a mutation in lamin A, which results in misshapen cell nuclei and DNA damage. Remodelin is a 2-thiazolylhydrazone derivative that, at 10 µM, improves nuclear architecture, chromatin...

TTC is a redox indicator used to detect cellular respiration. It is primarily reduced by Complex I in mitochondria and, under anaerobic conditions, is completely reduced to an insoluble red 1,3,5-triphenylformazan. TTC assays are typically used as a mitochondrial redox potential indicator for cell death.Formal Name:...

Chlorhexidine is a bis(biguanide) antimicrobial disinfectant and antiseptic agent. It inhibits growth of clinical methicillin-resistant S. aureus (MRSA) isolates (MIC90 = 4 µg/ml). It is also active against canine isolates of MRSA, methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. pseudintermedius...

Nitro Blue Tetrazolium (NBT) is a chromogenic substrate that, like other tetrazolium compounds, can be reduced to produce a colored formazan derivative. It is used in the "NBT test" to evaluate the activity of NADPH oxidase in phagocytes, which results in the production of blue reduced NBT formazan in normal cells...

Amoxapine is a tetracyclic antidepressant with a wide range of pharmacological effects. It inhibits norepinephrine and serotonin reuptake, binding the respective transporters with Kd values of 16 and 58 nM. It has also been shown to act as either an antagonist or inverse agonist at serotonin 5-HT2A, 2B, 2C, 3, 6, 7...

Rhein is an anthraquinone derivative that has been found in R. rhabarbarum and a metabolite of diacerein (Cay-11710) that has diverse biological activities, including anticancer, antioxidant, and anti-inflammatory activities. It induces cell cycle arrest at the S phase and inhibits the proliferation of HepG2 cells...