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Oncostatin M (OSM) is a cytokine originally isolated from medium conditioned by PMA-treated U-937 human histiocytic leukemia cells based on its ability to inhibit growth of A375 melanoma cells. The human OSM cDNA encodes a 252aa pre-pro-OSM polypeptide with a 25 residue hydrophobic signal peptide and a hydrophilic...

Oncostatin M (OSM) is a member of the interleukin-6 family of cytokines. Of these cytokines, OSM is closely related structually, genetically and functionally to leukemia inhibitory factor. However, OSM-specific biological activities have been reported in hematopoiesis and liver development. Applications: Suitable...

Oncostatin M is an important growth regulating cytokine that affects variably a number of tumor and normal cells. Oncostatin M exerts inhibitory effects on the growth of A375 melanoma and other cancer cells, but augments the growth of normal fibroblasts, AIDS-related Kaposi sarcoma cells, and other certain cells....

OSM, also known as Oncostatin M, is a pleiotropic cytokine that belongs to the interleukin 6 group of cytokines. Of these cytokines it most closely resembles leukemia inhibitory factor (LIF) in both structure and function. However, it is as yet poorly defined and is proving important in liver development,...

Oncostatin M Receptor beta (OSM Rb) is a type I transmembrane protein that binds OSM with low affinity by itself and high affinity as an OSM Rb/gp130 heterodimer. OSM Rb is widely expressed and transduces signals involved in hematopoiesis, liver development, peripheral neuron repair and epithelial cell function....

Oncostatin M receptor beta (OSM Rb) is a type I transmembrane protein that binds OSM with low affinity. The association of OSM Rb with gp130 produces a high affinity OSM receptor heterodimer. OSM Rabbit is expressed in a wide variety of cell types and transduces signals involved in hematopoiesis, liver development,...

Applications: , Suitable for use in Flow Cytometry, Direct ELISA and Western Blot. Other applications not tested. Recommended Dilution: Flow Cytometry: 25ug/ml use 10ul to label 10e6 cells. , Direct ELISA: 0.5-1.0ug/ml detection limit for rhOSM RBeta is ~0.5ng/well., Western Blot: 0.1ug/ml detection limit for rhOSM...

BAPTA and its derivatives are calcium chelators that are commonly used to form calcium buffers with well-defined calcium concentrations. By injecting the chelators into cells or by incubating cells with the AM ester form of the chelators, one can control the cytosolic calcium concentration, an important means to...