ONO-AE3-208

ONO-AE3-208
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay14522-1 1 mg -

6 - 10 business days*

60.00€
Cay14522-5 5 mg -

6 - 10 business days*

175.00€
Cay14522-10 10 mg -

6 - 10 business days*

287.00€
Cay14522-50 50 mg -

6 - 10 business days*

1,196.00€
 
ONO-AE3-208 is an antagonist of the EP4 receptor (Ki = 1.3 nM) which less potently affects EP3,... more
Product information "ONO-AE3-208"
ONO-AE3-208 is an antagonist of the EP4 receptor (Ki = 1.3 nM) which less potently affects EP3, FP, and TP receptors (Kis = 30, 790, and 2,400 nM, respectively) and is without effect on other prostanoid receptors. In wild type mice, it mimics deletion of EP4 by producing severe colitis, with epithelial loss, crypt damage, and inflammation, after treatment with 3% dextran sodium sulfate. ONO-AE3-208 has also been used to implicate EP4 signaling in immune and autoimmune responses, inflammation, and cancer.Formal Name: 4-cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]-benzenebutanoic acid. CAS Number: 402473-54-5. Molecular Formula: C24H21FN2O3. Formula Weight: 404.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 10 mg/ml. lambdamax: 223, 286 nm. SMILES: FC1=CC=C(C(C(NC2=CC(C#N)=CC=C2CCCC(O)=O)=O)C)C3=CC=CC=C31. InChi Code: InChI=1S/C24H21FN2O3/c1-15(18-11-12-21(25)20-7-3-2-6-19(18)20)24(30)27-22-13-16(14-26)9-10-17(22)5-4-8-23(28)29/h2-3,6-7,9-13,15H,4-5,8H2,1H3,(H,27,30)(H,28,29). InChi Key: MTDIMKNAJUQTIO-UHFFFAOYSA-N.
Keywords: 4-cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]-benzenebutanoic acid
Supplier: Cayman Chemical
Supplier-Nr: 14522

Properties

Application: EP4 receptor antagonist
MW: 404.4 D
Formula: C24H21FN2O3
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 402473-54-5| Matching products
KEGG ID : K04261 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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