- Search results for AG-CR1-3500
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30 products were found matching "AG-CR1-3500"!
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Item number: AG-CR1-3500-M010
Potent and highly selective, irreversible inhibitor of soluble guanylyl cyclase (sGC), The binding is competitive with nitric oxide (NO), Tool to elucidate the nitric oxide (NO)-cGMP pathway. Apoptosis inhibitor Inhibits growth and migration of prostate cancer cells independent of its effects on GMP levels.
Keywords: | 1H-[1,2,4]Oxadiazole[4,3-a]quinoxalin-1-one |
Application: | Soluble guanylyl cyclase inhibitor |
CAS | 41443-28-1 |
MW: | 187,2 D |
From 66.00€
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Item number: AG-CR1-3550-M001
CRT0066101 is an inhibitor of all three PKD isoforms (IC50s = 1, 2.5, and 2 nM for PKD1, PKD2 and PKD3, respectively). It exhibits selectivity for PKD against a panel of >90 protein kinases, including PKCalpha, PKBalpha, MEK, ERK, c-Raf, c-Src and c-Abl. PKD family members play an important role in regulating...
Keywords: | 2-[4-[[(2R)-2-Aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)-phenol . hydrochloride |
Application: | Protein kinase D (PKD1 / PKD2 / PKD3) inhibitor |
CAS | 1781742-22-0 |
MW: | 447.8 D |
50.00€
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Item number: AG-CR1-3554-M100
Inosine, an intermediate in purine metabolism, consists of hypoxanthine and ribose. It is an inert purine nucleoside formed by breakdown of adenosine (deamination, known as A-to-I editing that occurs in tRNA and mRNA) or also is generated by the action of 5'-nucleotidase on inosine monophosphate (IMP). Inosine has...
Keywords: | 9-beta-D-Ribofuranosylhypoxanthine, NSC 20262, Hypoxanthine 9-beta-D-ribofuranoside |
CAS | 58-63-9 |
MW: | 268,2 D |
From 22.00€
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Item number: AG-CR1-3639-M500
White to off-white or pale yellow solid. Soluble in DMSO (20mg/ml), 100% ethanol (20mg/ml) or methanol (5mg/ml). Slightly soluble in water (~1mg/ml) and PBS (3mg/ml). Cell permeable and water soluble derivative of vitamin E, Potent antioxidant. Efficiently prevents formation of different reactive oxygen species,...
Keywords: | (±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid, Trolox C |
Application: | Potent antioxidant |
CAS | 53188-07-1 |
MW: | 250,3 D |
From 39.00€
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Item number: AG-CR1-3512-M500
Cell permeable protein kinase C (PKC) inhibitor. Inhibits also protein kinase A (PKA).
Keywords: | 3-Isobutyl 1-methylxanthine, NSC 165960, EINECS 249-259-3 |
Application: | Phosphodiesterase inhibitor |
CAS | 28822-58-4 |
MW: | 222,3 D |
From 121.00€
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Item number: AG-CR1-3586-M100
Synthetic. Substrate for the electrochemical measurement of alkaline phosphatase.
Keywords: | 4-APP, 4-Aminobenzenephosphoric sodium, PNPP, p-Nitrophenyl phosphate |
Application: | Alkaline phosphatase substrate |
CAS | 52331-30-3 |
MW: | 211,3 D |
From 33.00€
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Item number: AG-CR1-3570-M100
Antidiabetic, hypoglycemic agent. Potent and selective peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist. Potent insulin sensitizing agent binding to the PPAR receptors in fat cells and making the cells more responsive to insulin. Ameliorates insulin resistance. Improves blood pressure and...
Keywords: | BRL 49653, HSDB 7555, TDZ 01 |
Application: | PPAR-gamma agonist |
Host: | Synthetic |
CAS | 122320-73-4 |
MW: | 357,4 D |
From 33.00€
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Item number: AG-CR1-3588-C500
Synthetic. Potent STING ligand. Second messenger in human and mouse cells that triggers interferon production in response to cytosolic DNA. Binding to STING leads to activation of IRF3 (IFN regulatory factor 3) and the induction of interferon-beta. First cyclic nucleotide in metazoa. Plays a role in bacterial...
Keywords: | cyclic (Adenosine Monophosphate-Guanosine Monophosphate), cyclic GMP-AMP, c-(GpAp) |
Application: | Potent STING ligand, Second messenger |
CAS | 849214-04-6 |
MW: | 720,4 D |
From 94.00€
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Item number: AG-CR1-3597-M100
White to off-white solid. Soluble in DMSO, DMF, ethanol or water. Potent cell permeable and selective inhibitor of phosphatidyl-inositol 3-kinase (PI3K), Blocks class I, class II and class III PI3Ks, including some downstream targets, Blocks class I PI3K persistently and class III PI3K transiently, Induces autophagy...
Keywords: | 3-MA, 3MeA, 6-Amino-3-methylpurine, NSC 66389 |
Application: | Potent cell permeable and selective PI3 kinase inhibitor |
CAS | 5142-23-4 |
MW: | 149,2 D |
From 39.00€
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Item number: AG-CR1-3651-C500
Pale yellow solid. Soluble in DMSO. Potent selective membrane-permeable DYRK1A (IC50=181nM) and DYRK1B inhibitor. Off-target inhibition of CLK1, CLK4 and Haspin/GSG2, Shows no inhibitory effects on monoamine oxidase A (MAO A), Inhibited the cotranslational tyrosine autophosphorylation of DYRK1A and threonine...
Keywords: | 2-(1-Chloro-7-methoxy-9H-pyrido[3,4-b]indol-9-yl)acetonitrile, AnnH75 |
Application: | Potent selective membrane-permeable DYRK1A / DYRK1B inhibitor |
MW: | 271,7 D |
154.00€
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Item number: AG-CR1-3572-M100
Potent anti-cancer compound. Induces apoptosis in normal and tumor cell lines. DNA Topoisomerase II activity inhibitor. Increases Topo II-mediated DNA breakage primarily by inhibiting the ability of the enzyme to religate cleaved nucleic acid molecules. Does not lead to immediate block of DNS synthesis, induces a...
Keywords: | VP-16-213, NSC 141540 |
Application: | Apoptosis Inducer |
Host: | Semisynthetic |
CAS | 33419-42-0 |
MW: | 588,6 D |
From 33.00€
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Item number: AG-CR1-3592-M100
White to off-white powder. Soluble in DMSO or water. Slightly soluble in methanol. Insoluble in ethanol. Potent platinum-based antineoplastic agent with wide spectrum anticancer activity, Anticancer compound. Forms inter- and intrastrand DNA adducts/crosslinks, consequently blocking DNA replication and transcription...
Keywords: | Diaminocyclohexane oxalatoplatinum, 1-OHP, ACT 078, RP 54780, NSC 266046 |
Application: | Apoptosis inducer, DNA crosslinker |
CAS | 61825-94-3 |
MW: | 397,3 D |
From 22.00€
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