- Search results for 50885
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6 products were found matching "50885"!
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Item number: 250885.100
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase...
Application: | IF, IP, WB |
Host: | Rabbit |
Species reactivity: | human |
744.00€
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Item number: 150885.100
Applications:, Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:8000, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C....
Application: | ELISA, WB |
Host: | Goat |
Species reactivity: | human |
909.00€
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Item number: Cay16643-1
B-Raf is a MAP kinase kinase kinase, which functions downstream of Ras family GTPases to activate MEK1/2 and ERK1/2 signaling. Mutations of B-Raf, particularly at Val600, are common in melanomas and melanocytic nevi. SB-590885 is a potent inhibitor of B-Raf (Kd = 0.3 nM). It less effectively inhibits c-Raf (Ki =...
Keywords: | 5-[2-[4-[2-(dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime |
Application: | Potent B-Raf inhibitor |
CAS | 405554-55-4 |
MW: | 453.5 D |
From 66.00€
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Item number: LKT-S0459.1
Potent B-Raf inhibitor, selective for B-Raf against 46 other kinases. Decreases anchorage-independent growth of melanoma cell lines. Inhibits ERK phosphorylation and proliferation in tumor cells expressing B-Raf.
Keywords: | SB590885, (E)-5-(2-(4-(2-(dimethylamino)ethoxy)phenyl)-4-(pyridin-4-yl)-1H-imidazol-5-yl)-2,3-dihydroinden-1-one oxime |
Application: | B-Raf inhibitor |
CAS | 405554-55-4 |
MW: | 453.54 D |
From 115.00€
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Item number: SYN-1077-M100
Soluble in DMSO or ethanol. SB-590885 is a novel, potent and selective small molecule inhibitor of B-Raf kinase, with a Ki of 0.16nM. It shows an 11-fold greater selectivity for B-Raf over c-Raf. It was used to address the dependence of MAPK signalling and tumor cell growth on B-Raf kinase activity. Target: ARaf -...
Keywords: | SB-590885 |
Application: | BRAF inhibitor |
CAS | 405554-55-4 |
MW: | 453,5 D |
Please request pricing for this article.
Item number: ABE-32-5088-25
Source : Escherichia Coli. TIGAR Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 283 amino acids (including the 270 residues of full-length TIGAR and a 13-residue C-terminal TAT peptide) and having a molecular mass of 31.7kDa. The TIGAR is purified by proprietary...
554.00€
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