(-)-Nutlin-3

(-)-Nutlin-3 is an inhibitor of the protein-protein interaction between p53 and Mdm2 (IC50 = 0.09 µM). It increases p53 levels, induces apoptosis, and reduces cell viability in HCT116, SJSA-1, and RKO cells that express wild-type p53 but not MDA-MB-435 or SW480 cells expressing mutant p53. (-)-Nutlin-3 (200 mg/kg) reduces tumor volume in SJSA-1, MHM, LNCaP, and 22Rv1 mouse xenograft models.Formal Name: 4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone. CAS Number: 675576-98-4. Synonyms: Nutlin 3a. Molecular Formula: C30H30Cl2N4O4. Formula Weight: 581.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.1 mg/ml. SMILES: ClC1=CC=C([C@@H]2[C@H](C3=CC=C(Cl)C=C3)N=C(C4=CC=C(OC)C=C4OC(C)C)N2C(N5CCN([H])C(C5)=O)=O)C=C1. InChi Code: InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m0/s1. InChi Key: BDUHCSBCVGXTJM-WUFINQPMSA-N.