Nimesulide

Nimesulide
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay70640-1000 1 g -

6 - 10 business days*

24.00€
Cay70640-5000 5 g -

6 - 10 business days*

84.00€
Cay70640-25000 25 g -

6 - 10 business days*

294.00€
 
Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) and COX-2 inhibitor (IC50s = 1.27... more
Product information "Nimesulide"
Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) and COX-2 inhibitor (IC50s = 1.27 and 0.03 µM for the human and ovine enzymes, respectively). It is selective for COX-2 over COX-1 (IC50s = 70 and 22 µM for the human and ovine enzymes, respectively). Nimesulide also inhibits sodium-dependent neutral amino acid transporter (B0AT1) with an IC50 value of 23 µM for the rat kidney transporter. It inhibits infection-induced increases in brain prostaglandin E2 (PGE2, Cay-14010) levels, as well as reduces pyresis (ED50 = 0.3 mg/kg), in yeast-infected rats. Nimesulide (2.9 mg/kg) inhibits formalin-induced hindpaw thermal hyperalgesia in rats.Formal Name: N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide. CAS Number: 51803-78-2. Synonyms: R805. Molecular Formula: C13H12N2O5S. Formula Weight: 308.3. Purity: >99%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml, Ethanol: 1 mg/ml. SMILES: O=S(NC1=C(OC2=CC=CC=C2)C=C([N+]([O-])=O)C=C1)(C)=O. InChi Code: InChI=1S/C13H12N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9,14H,1H3. InChi Key: HYWYRSMBCFDLJT-UHFFFAOYSA-N.
Keywords: R805, N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide
Supplier: Cayman Chemical
Supplier-Nr: 70640

Properties

Application: COX-2 inhibitor
MW: 308.3 D
Formula: C13H12N2O5S
Purity: >99%
Format: Crystalline Solid

Database Information

CAS : 51803-78-2| Matching products
KEGG ID : K11987 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H301
P Phrases: P264, P270, P301+310, P321, P330, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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