Nigericin is a lipophilic potassium ionophore that has been found in S. hygroscopicus. It mediates neutral antiport of potassium and proton ions across mitochondrial membranes. Nigericin (10 µM) induces T. gondii egress in infected human foreskin fibroblasts (HFFs). It also induces NOD-like receptor protein 3...

Chetomin is a natural product isolated from Chaetomium species which has antibacterial and antifungal properties. It is a small molecule inhibitor of hypoxia-inducible factor (HIF) signaling, disrupting the binding of HIF-1alpha and HIF-2alpha to p300 at low nanomolar concentrations. Chetomin effectively attenuates...

L-Mimosine is a non-protein amino acid that can be isolated from certain plants and fungi. It chelates iron and copper and has been shown to reduce iron overload in animal models. L-Mimosine inhibits certain enzymes that contain iron or copper, including arginase (IC50 = 3.7 µM), polyphenoloxidase, and dopamine...