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Nerve growth factor (NGF) is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons. Source: DNA sequence encoding the human beta NGF protein sequence (containing the signal peptide,...

p75 neurotrophin receptor, also named low affinity NGF receptor (NGF R), is a type I transmembrane protein that belongs to the tumor necrosis factor receptor family. NGF R cDNA encodes a 427aa residue precursor protein with a 28aa residue signal peptide, a 222aa residue extracellular domain, a 22aa residue...

The low affinity NGFR (Nerve growth factor receptor) is a 75kDa membrane-spanning glycoprotein lacking intrinsic tyrosine kinase activity. p75NGFR interacts with TrkA, the high affinity NGF receptor and potentiates TrkA signaling at low NGF concentrations. The p75 receptor binds nerve growth factor, brain-derived...

Nerve Growth Factor Receptor, p75NTR, generated by Chandlers et al. p75NTR, was originally discovered as a low affinity nerve growth factor receptor. Later it was found that it was the receptor for all neurotrophins. It mediates signals of neurotrophins for neuronal survival, apoptosis, neurite outgrowth and...

Mouse NGF (2.5S) was isolated from mouse submaxillary glands by method of Mobley et al (1976) and is a form of b-NGF that has identical biological properties. NGF is known to regulate the survival and development of certain sympathetic and sensory neurons. It is a dimer with 2 identical polypeptide chains and...

Nerve growth factor receptor (NGFR) is also referred to as p75(NTR) due to its molecular mass and its ability to bind at low affinity not only NGF (see 162030), but also other neurotrophins, including brain-derived neurotrophic factor (BDNF, 113505), neurotrophin-3 (NTF3, 162660), and neurotrophin-4/5 (NTF5,...

The p75 low affinity human Nerve Growth Factor receptor (TNFRSF16) is expressed on a variety of tissue types including a subset of splenic and nodal lymphocytes. Presence of this receptor supports uptake of intracellular calcium, but not mobilization(3). Its immunological role has not yet been elucidated. NGFR-muIg...

Nerve growth factor receptor (NGFR) is also referred to as p75(NTR) due to its molecular mass and its ability to bind at low affinity not only NGF, but also other neurotrophins, including brain-derived neurotrophic factor (BDNF, 113505), neurotrophin-3 (NTF3, 162660), and neurotrophin-4/5 (NTF5, 162662). At the time...

Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth...

Nerve Growth Factor Receptor (NGFR) is important for the development, differentiation, and survival of variety of neuronal and non-neuronal cells. Its action is mediated by binding two distinct receptors, the high affinity p140 and low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or Neurotrophin Receptor...

Nerve growth factor receptor (NGFR) is also referred to as p75(NTR) due to its molecular mass and its ability to bind at low affinity not only NGF (see 162030), but also other neurotrophins, including brain-derived neurotrophic factor (BDNF, 113505), neurotrophin-3 (NTF3, 162660), and neurotrophin-4/5 (NTF5,...

CD271 has been shown to interact with tropomyosin-receptor-kinase A (TrkA) forming the high-affinity NGF receptor, while CD271 can signal alone, constituting the low-affinity NGF receptor. When signalling alone, CD271 is involved in apoptosis, neurite outgrowth during development and myelination. Mutations and...