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Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand-induced and tumor necrosis factor-alpha (TNF-alpha) induced necrosis. Necrostatin-1 is an inhibitor of RIP1 kinase that prevents the death of TNF-alpha-treated FADD-deficient Jurkat cells with an EC50 value of 490 nM. It has been used to investigate the pathological importance of necroptosis in ischemic brain injury and myocardial infarction.Formal Name: 5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone. CAS Number: 4311-88-0. Synonyms: Nec-1. Molecular Formula: C13H13N3OS. Formula Weight: 259.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.50 mg/ml, DMSO: 14 mg/ml, Ethanol: 3 mg/ml. lambdamax: 220, 266 nm. SMILES: O=C(C(N1)CC2=CNC3=CC=CC=C32)N(C)C1=S. InChi Code: InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18). InChi Key: TXUWMXQFNYDOEZ-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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