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Naringenin is a citrus-derived flavonoid that inhibits CYP3A4 activity in human liver microsomes... more
Product information "Naringenin"
Naringenin is a citrus-derived flavonoid that inhibits CYP3A4 activity in human liver microsomes (IC50s = 139-188 µM). At 100 mg/kg/day, naringenin selectively inhibits the transcription of Smad3 and directly down-regulates TGF-beta1, significantly reducing lung metastasis in mice with bleomycin-induced pulmonary fibrosis. Naringenin demonstrates both lipid lowering and insulin-like properties in low-density lipoprotein (LDL) receptor-deficient mice fed a Western diet containing 1-3% naringenin by correcting VLDL overproduction, ameliorating hepatic steatosis, and attenuating dyslipidemia without affecting caloric intake or fat absorption.Formal Name: 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 67604-48-2. Synonyms: S-Dihydrogenistein, NSC 11855, NSC 34875, Salipurol. Molecular Formula: C15H12O5. Formula Weight: 272.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.50 mg/ml, DMSO: 5 mg/ml, Ethanol: 2.5 mg/ml. lambdamax: 213, 225, 289 nm. SMILES: OC(C=C1)=CC=C1C2CC(C3=C(O)C=C(O)C=C3O2)=O. InChi Code: InChI=1S/C15H12O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-6,13,16-18H,7H2. InChi Key: FTVWIRXFELQLPI-UHFFFAOYSA-N.
Keywords: | NSC 11855, NSC 34875, S-Dihydrogenistein, Salipurol, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
Supplier: | Cayman Chemical |
Supplier-Nr: | 14173 |
Properties
Application: | CYP3A4 inhibitor |
MW: | 272.3 D |
Formula: | C15H12O5 |
Purity: | >98% |
Format: | Crystalline Solid |
Database Information
CAS : | 67604-48-2| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
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H Phrases: | H315, H319, H335 |
P Phrases: | P261, P264, P271, P280, P312, P321, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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