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Nampt (Visfatin/PBEF) (human, rec.)

ART NR.: AG-40A-0031-C010 (10 µg)
AG-40A-0031-C050 (50 µg)

Hersteller: Adipogen

Datenblatt



MSDS

Anwendungen: Bioassays

Exprimiert in: Human cells

Ursprungs-Art: human

MW: 52 kD

Format: lyophilized

UniProt ID: P43490
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Schlagworte: Nicotinamide Phosphoribosyltransferase, Pre-B Cell Colony Enhancing Factor 1, PBEF1

AG-40A-0031-C010

10 µg

132 €

AG-40A-0031-C050

50 µg

424 €

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Bemerkungen: Extracellular human Nampt (visfatin/PBEF) (amino acids 1-491) is fused at the N-terminus to a FLAG(R)-tag. Shows adipogenic effects in stimulated differentiating 3T3-L1 cells. Lyophilized from PBS. Nicotinamide phosphoribosyltransferase (Nampt, pre-B cell colony-enhancing factor, PBEF, Visfatin) is an 52kDa adipokine secreted by adipose tissue and involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD). Two forms of Nampt exist, an intracellular form (iNampt) and an extracellular form (eNampt). While the function of iNampt as an essential and rate-limiting NAD biosynthetic enzyme is well established, the physiological role of eNampt is still a matter of debate. Nampt has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.
Image Art AG-40A-0031-C050 Adipogen Nampt (Visfatin/PBEF) (human, rec.)
Figure legend: Datenblatt ansehen

Spezifikationen

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