NVP-AUY922

NVP-AUY922
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10012698-5 5 mg -

6 - 10 business days*

205.00€
Cay10012698-10 10 mg -

6 - 10 business days*

325.00€
 
Hsp90 is a molecular chaperone of many different kinases, transcription factors, and hormone... more
Product information "NVP-AUY922"
Hsp90 is a molecular chaperone of many different kinases, transcription factors, and hormone receptors involved in signal transduction, cell cycle regulation, and apoptosis. In addition to its important function in normal cell homeostasis, a high affinity form of Hsp90 is prevalent in tumor cells. Hsp90 inhibition has been associated with the degradation of oncogenic client proteins. NVP-AUY922 is a Hsp90 inhibitor (IC50 = 21 nM in a FP binding assay) that prevents the proliferation of a range of human cancer cell lines in vitro with GI50s averaging 9 nM. In a human colon cancer xenograft model, 50 mg/kg NVP-AUY922 inhibits tumor growth by ~50% compared to vehicle controls. Unlike some first generation Hsp90 inhibitors that are quickly glucuronidated, NVP-AUY922 is retained in tumors in vivo when administered at 4 mg/kg i.p. by cassette dosing in tumor-bearing mice.Formal Name: 5-[2,4-dihydroxy-5-(1-methylethyl)phenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide. CAS Number: 747412-49-3. Synonyms: VER 52296. Molecular Formula: C26H31N3O5. Formula Weight: 465.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMSO: 5 mg/ml, Ethanol: 14 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 310 nm. SMILES: OC1=CC(O)=C(C(C)C)C=C1C2=C(C3=CC=C(CN4CCOCC4)C=C3)C(C(NCC)=O)=NO2. InChi Code: InChI=1S/C26H31N3O5/c1-4-27-26(32)24-23(18-7-5-17(6-8-18)15-29-9-11-33-12-10-29)25(34-28-24)20-13-19(16(2)3)21(30)14-22(20)31/h5-8,13-14,16,30-31H,4,9-12,15H2,1-3H3,(H,27,32). InChi Key: NDAZATDQFDPQBD-UHFFFAOYSA-N.
Keywords: VER 52296, 5-[2,4-dihydroxy-5-(1-methylethyl)phenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide
Supplier: Cayman Chemical
Supplier-Nr: 10012698

Properties

Application: Hsp90 Inhibitor
MW: 465.5 D
Formula: C26H31N3O5
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 747412-49-3| Matching products
KEGG ID : K04079 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302, H319, H335
P Phrases: P261, P264, P270, P271, P280, P312, P330, P301+P310, P304+P340, P305+P351+P338, P337+P313, P405, P403+P233, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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