NVP-AEW541 (hydrochloride)

NVP-AEW541 (hydrochloride)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13641-500 500 µg -

6 - 10 business days*

109.00€
Cay13641-1 1 mg -

6 - 10 business days*

158.00€
Cay13641-5 5 mg -

6 - 10 business days*

586.00€
Cay13641-10 10 mg -

6 - 10 business days*

1,024.00€
 
NVP-AEW541 is an inhibitor of insulin-like growth factor 1 receptor (IGF-1R, IC50 = 0.15 µM in a... more
Product information "NVP-AEW541 (hydrochloride)"
NVP-AEW541 is an inhibitor of insulin-like growth factor 1 receptor (IGF-1R, IC50 = 0.15 µM in a cell-free assay). It is selective for IGF-1R over a panel of 20 kinases but also inhibits the insulin receptor (InsR), VEGFR1, FMS-related tyrosine kinase 3 (FLT3), and tunica interna endothelial cell kinase 2 (Tie2, IC50s = 0.14, 0.6, 0.42, and 0.53 µM, respectively, in cell-free assays). NVP-AEW541 selectively inhibits the autophosphorylation of IGF-1R over InsR, EGFR, PDGFR, c-Kit, and Bcr-Abl in cells (IC50s = 0.086, 2.3, >10, >10, >5, and >10 µM, respectively). It reduces tumor volume in an NWT-21 murine fibrosarcoma model when administered at doses of 20, 30, or 50 mg/kg twice per day.Formal Name: 7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, dihydrochloride. CAS Number: 2320261-63-8. Molecular Formula: C27H29N5O . 2HCl. Formula Weight: 512.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Ethanol: 0.3 mg/ml, PBS (pH 7.2): 2.5 mg/ml. lambdamax: 288 nm. SMILES: NC1=C2C(N([C@@H]3C[C@H](CN4CCC4)C3)C=C2C5=CC=CC(OCC6=CC=CC=C6)=C5)=NC=N1.Cl.Cl. InChi Code: InChI=1S/C16H16N6O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12/h3-8,20,23H,1-2H3,(H2,17,18,19). InChi Key: MFAQYJIYDMLAIM-UHFFFAOYSA-N.
Keywords: 7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, dihydrochloride
Supplier: Cayman Chemical
Supplier-Nr: 13641

Properties

Application: IGF-1R kinase inhibitor
MW: 512.5 D
Formula: C27H29N5O . 2HCl
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 2320261-63-8| Matching products
KEGG ID : K05087 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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