8 products were found matching "Cay16268"!

The proto-oncogene serine/threonine-protein kinases, Pim-1 and Pim-2, are enzymes involved in cytokine signaling and participate in various signal transduction pathways, including cell growth, differentiation, and apoptosis. Their overexpression has been implicated in prostate cancer, some forms of leukemia, and...

P7C3 is an orally bioavailable and brain penetrant aminopropyl carbazole that exhibits proneurogenic and neuroprotective activity by preventing apoptosis of newly postmitotic neurons in the subgranular zone of the hippocampal dentate gyrus. At doses of 5 mg/kg and above, it has been shown to promote the survival of...

Meropenem is a carbapenem antibiotic. It is active against clinical isolates of Gram-positive and Gram-negative bacteria in vitro, including S. pneumoniae, H. influenzae, N. gonorrhoeae, E. coli, P. aeruginosa, C. difficile, and methicillin-susceptible and -resistant S. aureus (MICs = =0.008-8 µg/ml). It is...

Rifabutin is a rifamycin antibiotic. It is active against a variety of Gram-positive and Gram-negative bacteria, including 81 clinical isolates of H. pylori (MIC50 = 0.25 µg/ml), as well as S. aureus, S. pyogenes, and C. trachomatis (MICs = 0.004, 0.005, and ~0.008 µg/ml, respectively). Rifabutin (0.5 µg/ml) is also...

The VEGF receptors (VEGFRs) mediate signaling leading to angiogenesis, with VEGFR3 (FLT4), activated by VEGF isoforms VEGFC and VEGFD, primarily expressed on lymphatic endothelial cells and directing lymphangiogenesis. MAZ51 is an indolinone that selectively antagonizes the activation of VEGFR3 by VEGFC (IC50 = 1...

Fluprostenol is a metabolically stable analog of PGF2alpha with potent FP receptor agonist activity. Fluprostenol is the optically active enantiomer of fluprostenol and would be expected to have twice the potency as the racemic mixture. Fluprostenol inhibits PGF2alpha binding to human and rat FP receptors with IC50...

N-nonanoyl-L-Homoserine lactone is an N-acylated homoserine lactone and a bacterial quorum-sensing signaling molecule. It induces GFP production in an E. coli reporter strain expressing the V. fischeri LuxR-PluxI quorum-sensing operon when used at concentrations ranging from 100 to 1,000 nM.Formal Name:...

Cyclothiocurvularin A is a macrocyclic polyketide that has been found in Penicillium.Formal Name: (1R,3aR,7S,15aR)-1,12,14-trihydroxy-7-methyl-9,15-dioxo-1,2,3a,4,6,7,9,10,15,15a-decahydro-5H-benzo[d]thieno[3,2-g][1]oxacyclododecine-1-carboxylic acid. Molecular Formula: C19H22O8S. Formula Weight: 410.4. Purity:...