NQDI-1

Apoptosis signal-regulating kinase 1 (ASK1) is the ubiquitously expressed mitogen-activated protein kinase kinase kinase 5 involved in a wide range of biological functions that are dependent on cell survival or death. NQDI-1 is a specific inhibitor of ASK1 (IC50 = 3 µM, Ki = 500 nM) that demonstrates potent selectivity against various serine/threonine and tyrosine protein kinases. It has been used to promote survival of induced pluripotent stem cell populations and to protect neurons from reactive oxygen species-induced apoptosis in a model of ischemia.Formal Name: 2,7-dihydro-2,7-dioxo-3H-naphtho[1,2,3-de]quinoline-1-carboxylic acid, ethyl ester. CAS Number: 175026-96-7. Molecular Formula: C19H13NO4. Formula Weight: 319.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMF:PBS(pH7.2) (1:2): 0.3 mg/ml, DMSO: 1 mg/ml. lambdamax: 217, 313, 334, 346, 402 nm. SMILES: O=C(C1=C2C(N3)=CC=C1)C4=CC=CC=C4C2=C(C(OCC)=O)C3=O. InChi Code: InChI=1S/C19H13NO4/c1-2-24-19(23)16-15-10-6-3-4-7-11(10)17(21)12-8-5-9-13(14(12)15)20-18(16)22/h3-9H,2H2,1H3,(H,20,22). InChi Key: UFJGFNHRMPMALC-UHFFFAOYSA-N.