NO-Losartan A

NO-Losartan A
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10006456-1 1 mg -

6 - 10 business days*

26.00€
Cay10006456-5 5 mg -

6 - 10 business days*

105.00€
Cay10006456-10 10 mg -

6 - 10 business days*

185.00€
Cay10006456-50 50 mg -

6 - 10 business days*

797.00€
 
Angiotensin II is a hormone that plays an important role in regulating blood pressure. Elevated... more
Product information "NO-Losartan A"
Angiotensin II is a hormone that plays an important role in regulating blood pressure. Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT1) receptor. Losartan is a mammalian AT1 receptor antagonist with a Ki value of 5-20 nM. In humans, losartan effectively controls hypertension while protecting renal function. Nitric oxide (NO) causes vasodilation and also inhibits platelet and neutrophil aggregation in the endothelium. NO-losartan A possesses similar anti-hypertensive effects to losartan, with the addition of the vasodilating effects of NO release.Formal Name: [2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazol-5-yl] methyl ester. CAS Number: 791122-48-0. Molecular Formula: C30H28ClN7O5. Formula Weight: 602.0. Purity: >97%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH7.2)(1:5): .5 mg/ml. SMILES: CCCCc1nc(Cl)c(COC(=O)c2cccc(CO[N](=O)O)c2)n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1. InChi Code: InChI=1S/C30H28ClN7O5/c1-2-3-11-27-32-28(31)26(19-42-30(39)23-8-6-7-21(16-23)18-43-38(40)41)37(27)17-20-12-14-22(15-13-20)24-9-4-5-10-25(24)29-33-35-36-34-29/h4-10,12-16H,2-3,11,17-19H2,1H3,(H,33,34,35,36). InChi Key: MWJCPZGVGOVWQZ-UHFFFAOYSA-N.
Keywords: [2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazol-5-yl] methyl ester
Supplier: Cayman Chemical
Supplier-Nr: 10006456

Properties

Application: AT1 receptor antagonist
MW: 602 D
Formula: C30H28ClN7O5
Purity: >97%
Format: Crystalline Solid

Database Information

CAS : 791122-48-0| Matching products
KEGG ID : K04166 | Matching products

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319, H335
P Phrases: P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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