NF-kappaB (p50) (human, recombinant)

The NF-kappaB/Rel family of transcription factors is comprised of several structurally-related proteins that form homodimers and heterodimers and include p50/p105, p52/p100, RelA (p65), and c-Rel/NF-kappaB . Members of this family are responsible for regulating over 150 target genes, including the expression of inflammatory cytokines, chemokines, immunoreceptors, and cell adhesion molecules. Because of this, NF-kappaB has often been called a 'central mediator of the human immune response. Acting as dimers, these transcription factors bind to 10 base pair DNA sequences, collectively called kappaB sites thereby regulating expression of target genes. The most common Rel/NF-kappaB dimer in mammals contains (p50)-RelA (p50/p65) heterodimers and is called NF-kappaB. The importance of Rel/NF-kappaB transcription factors in human inflammation and certain diseases makes them attractive targets for potential therapeutics.Synonyms: NF-kappaB1, Nuclear Factor-kappaB (p50). Purity: >55%. Source: Human recombinant GST-tagged protein expressed in E. coli. Amino Acids: 1-433 (full length). MW: 74.5 kDa. Formulation: (Request formulation change), A solution in PBS, pH 7.4, containing 5 mM DTT and 20% glycerol. Applications: (+) WB. UniProt Accession #: P19838.