The NF-kappaB/Rel family of transcription factors is comprised of several structurally-related proteins that form homodimers and heterodimers and include p50/p105, p52/p100, RelA (p65), and c-Rel/NF-kappaB . Members of this family are responsible for regulating over 150 target genes, including the expression of...

(+)-Nutlin-3 is the enantiomer and less active form of the p53-Mdm2 protein-protein interaction inhibitor (-)-nutlin-3 (Cay-18585). It inhibits the interaction between p53 and Mdm2 150-fold less potently than (-)-nutlin-3 with an IC50 value of 13.6 µM. (+)-Nutlin-3 has been used as a negative control for the...

thio-Miltefosine is a sulfur-containing derivative of miltefosine (Cay-63280).Formal Name: 1-hexadecyl-thio-phosphorylcholine. CAS Number: 943022-11-5. Molecular Formula: C21H46NO3PS. Formula Weight: 423.6. Purity: >98%. Formulation: (Request formulation change), A neat oil. Solubility: DMF: .05 mg/ml, DMSO: .5...

The peroxisome proliferator-activated receptors (PPARs) alpha, gamma, and delta are ligand-activated transcription factors that play a key role in lipid homeostasis. Activation of PPARalpha results in increased clearance of triglyceride (TG) rich very low-density lipoprotein (VLDL) via a reduction in plasma levels...