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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay11633-50 | 50 µg | - |
6 - 10 business days* |
619.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Nuclear receptor corepressor 2 (NcoR2) is a transcriptional corepressor that plays an essential... more
Product information "NCOR2/SMRT (human recombinant)"
Nuclear receptor corepressor 2 (NcoR2) is a transcriptional corepressor that plays an essential role in the regulation of development and metabolism. Histone deacetylases (HDACs) can mediate nuclear receptor functions by forming co-repressor complexes with nuclear receptors in the absence of ligands. However, HDACs are primarily responsible for catalyzing the deacetylation of core histones. HDAC3, a class I HDAC related to the yeast HDAC Rpd, is inactive alone and requires binding with the deacetylase activation domain (DAD) of NcoR2 for activation. The deacetylation of core histones by HDACs results in the tightening of nucleosomal integrity, restriction of access to transcription factors, and the suppression of gene transcription. In addition, HDACs mediate other transcription regulatory pathways by associating with transcription factors, such as E2F, TFIIE, TFIIF, NF-kappaB, p300, Stat3, p53, and the retinoblastoma (Rb) protein. The modification of chromatin structure and other non-histone proteins by HDACs serves to control many complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation. Thus, dysregulation of HDACs, leading to an imbalance of acetylation and deacetylation, may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.Synonyms: CTG Repeat Protein 26, Nuclear Receptor Corepressor 2, Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor, SMAP 270, SMRT, T3 Receptor-Associating Factor, Thyroid-Retinoic-Acid-Receptor-Associated Corepressor, TRAC. Source: 50 µg of recombinant N-terminal GST-tagged protein expressed in E. coli. Amino Acids: 395-489 (partial protein). MW: 39 kDa. Formulation: (Request formulation change), 50 mM Tris-HCl, pH 8.0, with 138 mM sodium chloride, 20 mM glutathione, and 10% glycerol. UniProt Accession #: Q9Y618.
Keywords: | CTG Repeat Protein 26, Nuclear Receptor Corepressor 2, Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor, SMAP270, SMRT, T3 Receptor-Associating Factor, Thyroid-Retinoic-Acid-Receptor-Associated Corepressor, TRAC |
Supplier: | Cayman Chemical |
Supplier-Nr: | 11633 |
Properties
Application: | Enzyme assays |
Conjugate: | No |
MW: | 39,0 kD |
Database Information
KEGG ID : | K06065 | Matching products |
UniProt ID : | Q9Y618 | Matching products |
Gene ID | GeneID 9612 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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