NBQX (sodium salt)

Ionotropic glutamate receptors can be divided into three groups, depending on whether they are activated by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), kainate, or N-methyl-D-aspartate (NMDA). NBQX is a water-soluble receptor antagonist which targets both AMPA- and kainate-sensitive glutamate receptors (IC50 = 0.15 and 4.8 µM, respectively). It does not block the NMDA-sensitive glutamate receptor (IC50 = > 90 µM). NBQX can be used in isolated neurons, tissues, or in vivo.Formal Name: 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide, disodium salt. CAS Number: 479347-86-9. Molecular Formula: C12H6N4O6S . 2Na. Formula Weight: 380.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 20 mg/ml. lambdamax: 220, 271, 296, 357, 426 nm. SMILES: [O-]C1=NC2=C(N=C1[O-])C=C([N+]([O-])=O)C3=C2C=CC=C3S(N)(=O)=O.[Na+].[Na+]. InChi Code: InChI=1S/C12H8N4O6S.2Na/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6,,/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22),,/q,2*+1/p-2. InChi Key: SVJKYIUJRJEABK-UHFFFAOYSA-L.