N-(3-pyridyl)-Indomethacin amide

N-(3-pyridyl)-indomethacin amide (N-3PyIA) is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2. N-3PyIA selectively inhibits human recombinant COX-2 with an IC50 of 0.052 µM. It is about 1,300 times less potent as an inhibitor of ovine recombinant COX-1. However, N-3PyIA is not selective as an inhibitor of ovine seminal vesicular COX-1 and ovine placental COX-2. The IC50 values for ovine COX-1 and -2 are 75 and 50 µM, respectively.Formal Name: N-(3-pyridyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide. CAS Number: 261766-29-4. Synonyms: N-3PyIA. Molecular Formula: C24H20ClN3O3. Formula Weight: 433.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 8.8 mg/ml, DMF:PBS (5:3): 5.2 mg/ml, DMSO: 5.4 mg/ml, Ethanol: 3 mg/ml. lambdamax: 240 nm. SMILES: ClC1=CC=C(C(N2C(C=CC(OC)=C3)=C3C(CC(N([H])C4=CN=CC=C4)=O)=C2C)=O)C=C1. InChi Code: InChI=1S/C24H20ClN3O3/c1-15-20(13-23(29)27-18-4-3-11-26-14-18)21-12-19(31-2)9-10-22(21)28(15)24(30)16-5-7-17(25)8-6-16/h3-12,14H,13H2,1-2H3,(H,27,29). InChi Key: DTAPHQYAZUTCIG-UHFFFAOYSA-N.