Monoacylglycerol Lipase Inhibitor Screening Assay Kit

Monoacylglycerol Lipase Inhibitor Screening Assay Kit
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay705192-96 96 wells -

6 - 10 business days*

436.00€
 
The endocannabinoid system is a ubiquitous lipid signaling system that is involved in various... more
Product information "Monoacylglycerol Lipase Inhibitor Screening Assay Kit"
The endocannabinoid system is a ubiquitous lipid signaling system that is involved in various regulatory functions throughout the body. The main endocannabinoids are arachidonoyl ethanolamide (AEA) and 2-arachidonoyl glycerol (2-AG). They bind to G protein-coupled receptors, of which the cannabinoid (CB1) receptor is densely distributed in areas of the brain related to motor control, cognition, emotional responses, and homeostasis. Acting via the CB2 receptor in the peripheral tissues, the endocannabinoid system is one of the crucial modulators of the autonomic nervous system, the immune system, and microcirculation. Endocannabinoids are released upon demand from lipid precursors in a receptor-dependent manner. They are transported into cells by an apparently specific uptake system and degraded primarily by two enzymes, fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) resulting in the termination of their biological actions. FAAH, a serine hydrolase, can degrade many fatty acid amides, including AEA. Although FAAH can hydrolyze 2-AG, the main enzyme responsible for the inactivation of this monoglyceride is another serine hydrolase, MAGL. Finding inhibitors to these endocannabinoid hydrolases could offer another approach in the treatment of pain, obesity, and various neurological diseases, where higher endocannabinoid activity would be beneficial. An advantage of such enzyme inhibition over direct cannabinoid agonists could result in higher selectivity, as it would increase activity of the endocannabinoid system only at sites where on-going production of endocannabinoids is taking place. Cayman's Monoacylglycerol Lipase Inhibitor Screening Assay provides a convenient method for screening human MAGL inhibitors. MAGL hydrolyzes 4-nitrophenylacetate resulting in a yellow product, 4-nitrophenol, with an absorbance of 405-412 nm.Synonyms: MAGL, MGL.
Keywords: MAGL, MGL
Supplier: Cayman Chemical
Supplier-Nr: 705192

Properties

Application: MAGL inhibitor screening
Species reactivity: human
Format: Homog.

Database Information

KEGG ID : K01054 | Matching products
UniProt ID : Q99685 | Matching products

Handling & Safety

Storage: -80°C
Shipping: -80°C (International: -80°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H350, H400, H410
P Phrases: P201, P202, P210, P233, P240, P241, P242, P243, P273, P280, P303+361+353, P308+313, P370+378, P391, P403+235, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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