Macrophage inflammatory protein 1-alpha (MIP1-alpha, MIP-1a, CCL3, Chemokine (C-C motif) ligand 3, G

Macrophage Inflammatory Protein-1 (MIP-1,alpha) is part of the CC subfamily of the chemokine superfamily of chemoattractant cytokines. MIP-1& alpha affects the inflammatory response of blood monocytes, tissue macrophages, and T cells. MIP-1,alpha also enhances the formation of granulocyte-macrophage colonies stimulated by GM-CSF or M-CSF. Human MIP-1,alpha is composed of 69 aa residues with not possible N-linked glycosylation sites, and several possible O-linked sites. Human MIP-1,alpha is 60% homologous with human MIP-1, alpha, 75% homologous with murine MIP-1,alpha, and has been shown to be active on murine cells. Biological Activity: The biological activity of recombinant human MIP-1 alpha is determined by its use as a cofactor for CSF-dependent myelopoiesis. Storage and Stability: For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for 6 months.