Macrophage Inflammatory Protein-1 alpha (CCL3), rat recombinant (rrMIP-1a)

Monokine with inflammatory and chemokinetic properties. Has chemotactic activity for monocytes, neutrophils, eosinophils, basophils, and lymphocytes. Required for lung TNF-alpha production, neutrophil recruitment and subsequent lung injury and may function as an autocrine mediator for the macrophage production of TNF-alpha which in turn up-regulates vascular adhesion molecules required for neutrophil influx. This protein binds heparin. (www.uniprot.org) Produced in E.coli as a single, non-glycosylated, polypeptide chain containing 69 amino acids. CCL3 activates human granulocytes (neutrophils, eosinophils and basophils) which can lead to acute neutrophilic inflammation.