MTEP (hydrochloride)

MTEP (hydrochloride)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay14961-1 1 mg -

6 - 10 business days*

44.00€
Cay14961-5 5 mg -

6 - 10 business days*

98.00€
Cay14961-10 10 mg -

6 - 10 business days*

150.00€
Cay14961-50 50 mg -

6 - 10 business days*

636.00€
 
Glutamate, the major excitatory neurotransmitter in the brain, acts on both ionotropic and... more
Product information "MTEP (hydrochloride)"
Glutamate, the major excitatory neurotransmitter in the brain, acts on both ionotropic and metabotropic glutamate receptors. Excessive metabotropic glutamate receptor (mGluR) transmission has been linked to epilepsy, ischemia, pain, anxiety, and depression. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. MTEP is a negative allosteric modulator of the mGlu5a receptor subtype (Ki = 42 nM, IC50 = 110 nM). MTEP at 0.3 mg/kg produces antidepressant effects in several rodent models of depression. It also demonstrates neuroprotective potential by preventing excitotoxic neuronal damage when administered through either intrahippocampal or intraperitoneal injection. Additionally, MTEP demonstrates an anxiolytic-like phenotype in rodent models similar to that of benzodiazepines while lacking undesirable sedative and addictive effects.Formal Name: 3-[2-(2-methyl-4-thiazolyl)ethynyl]-pyridine, monohydrochloride. CAS Number: 1186195-60-7. Molecular Formula: C11H8N2S . HCl. Formula Weight: 236.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMSO: 15 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 283, 299 nm. SMILES: CC1=NC(C#CC2=CC=CN=C2)=CS1.Cl. InChi Code: InChI=1S/C11H8N2S.ClH/c1-9-13-11(8-14-9)5-4-10-3-2-6-12-7-10,/h2-3,6-8H,1H3,1H. InChi Key: YCIOJDKGCWAHLR-UHFFFAOYSA-N.
Keywords: 3-[2-(2-methyl-4-thiazolyl)ethynyl]-pyridine, monohydrochloride
Supplier: Cayman Chemical
Supplier-Nr: 14961

Properties

Application: mGlu5a receptor antagonist
MW: 236.7 D
Formula: C11H8N2S . HCl
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 1186195-60-7| Matching products
KEGG ID : K04604 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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