MMP9 (Q279R), C-terminal His-tag, human recombinant protein

Human matrix metallopeptidase-9 (MMP9), also known as gelatinase B, MANDP2, CLG4B, Macrophage gelatinase, GELB and EC 3.4.24, with Gln to Arg mutation on a.a. 279, GenBank Accession No. NM_004994), a.a. 20-707 (end) with C-terminal His-tag, MW=77.8 kDa, expressed in an HEK293 cell expression system. Protein function: May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-/-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. [The UniProt Consortium]