ML-7 (hydrochloride)

ML-7 inhibits smooth muscle myosin light chain kinase (MLCK) with a Ki value of 0.3 µM and displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs. It exhibits a 10-fold more potent inhibition of MLCK than its parent compound ML-9 (Cay-10010236).Formal Name: hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine, monohydrochloride. CAS Number: 110448-33-4. Molecular Formula: C15H17IN2O2S . HCl. Formula Weight: 452.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 1 mg/ml. lambdamax: 220, 238, 306 nm. SMILES: O=S(C1=CC=CC2=C1C=CC=C2I)(N3CCCNCC3)=O.Cl. InChi Code: InChI=1S/C15H17IN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18,/h1-2,4-7,17H,3,8-11H2,1H. InChi Key: KDDALCDYHZIZMH-UHFFFAOYSA-N.