- Search results for Cay15185
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10 products were found matching "Cay15185"!
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Item number: Cay15185-50
The KCNQ (Kv7) family of voltage-gated potassium (K+) channels consists of five members, KCNQ1-KCNQ5. KCNQ1-KCNQ5 are critical for setting up the excitation threshold of action potentials. KCNQ1 is expressed mainly in cardiac tissue, peripheral epithelial cells, and smooth muscle cells, while KCNQ2-KCNQ5 are...
Keywords: | CID-3111211, N-(2,4,6-trimethylphenyl)-bicyclo[2.2.1]heptane-2-carboxamide |
Application: | KCNQ2 / KCNQ4 activator |
CAS | 489402-47-3 |
MW: | 257.4 D |
From 92.00€
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Item number: Cay15188-5
ML-239 is an inhibitor of cancer stem cells, displaying greater than 23-fold selective inhibition of a breast cancer stem cell-like cell line (EC50 = 1.18 µM) over an isogenic control cell line (EC50 = 27.6 µM). It is also toxic to the breast carcinoma cell line MDA-MB-231. ML-239 alters the expression of genes in...
Keywords: | CID-49843203, 2-(2,4,6-trichlorophenoxy)-acetic acid, (2E)-2-(1H-pyrrol-2-ylmethylene)hydrazide |
Application: | Cancer stem cell inhibitor |
CAS | 1378872-36-6 |
MW: | 346.6 D |
From 43.00€
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Item number: Cay15183-5
ML-192 is an antagonist of GPR55 (IC50 = 702 nM). It is selective for GPR55 over the cannabinoid (CB) receptors CB1 and CB2, as well as GPR35 (IC50s = >32 µM).Formal Name: 2-furanyl[4-(5,6,7,8-tetrahydro-2-methyl[1]benzothieno[2,3-d]pyrimidin-4-yl)-1-piperazinyl]-methanone. CAS Number: 460331-61-7. Synonyms:...
Keywords: | CID-1434953, 2-furanyl[4-(5,6,7,8-tetrahydro-2-methyl[1]benzothieno[2,3-d]pyrimidin-4-yl)-1-piperazinyl]-methanone |
Application: | GPR55 antagonist |
CAS | 460331-61-7 |
MW: | 382.5 D |
From 97.00€
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Item number: Cay15181-5
ML-180 is an inverse agonist of liver receptor homolog-1 (LRH-1, IC50 = 3.7 µM) with maximum efficacy of 64% repression. It is inactive at the related steroidogenic factor-1 transcriptional activator. Through LRH-1, ML-180 alters the expression of haptoglobin and serum amyloid proteins A1 and A4, induces the death...
Keywords: | CID-3238389, SR1848, 6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-2,4(1H,3H)-pyrimidinedione |
Application: | NR5A2 inverse agonist |
CAS | 863588-32-3 |
MW: | 388.9 D |
From 50.00€
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Item number: Cay15187-5
The apelin receptor (APJ) signaling pathway mediates cardiovascular homeostasis and is involved in the pathogenesis of cardiovascular diseases. ML-233 is a novel APJ agonist (EC50 = 3.7 µM) that is >21-fold selective over the closely related angiotensin 1 receptor (EC50 = >79 µM).Formal Name:...
Keywords: | CID-46905036, (E)-4-methyl-5-(((phenylsulfonyl)oxy)imino)-[1,1'-bi(cyclohexane)]-3,6-dien-2-one |
Application: | APLNR agonist |
MW: | 359.4 D |
From 61.00€
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Item number: Cay15180-5
ML-179 is a potent inverse agonist of liver receptor homolog-1 (LRH-1) (IC50 = 320 nM) with maximum efficacy of 40% repression. It is inactive at the related steroidogenic factor-1 transcriptional activator. Through LRH-1, ML-180 alters the expression of haptoglobin and serum amyloid proteins A1 and A4, induces the...
Keywords: | CID-45100448, 3-cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]-2,4(1H,3H)-pyrimidinedione |
Application: | NR5A2 inverse agonist |
CAS | 1883548-87-5 |
MW: | 422.4 D |
From 60.00€
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Item number: Cay15184-5
ML-193 is a potent antagonist of GPR55 (IC50 = 221 nM). It displays selectivity for GPR55 over CB1, CB2, and GPR35. ML-193 inhibits GPR55-dependent ERK phosphorylation (IC50 = 65 nM) and blocks translocation of PKCbetaII. ML-193 blocks increases in intracellular calcium levels induced by lysophosphatidylinositol...
Keywords: | CID-1261822, N-[4-[[(3,4-dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide |
Application: | Potent GPR55 antagonist |
CAS | 713121-80-3 |
MW: | 527.6 D |
From 43.00€
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Item number: Cay15182-5
ML-191 is an antagonist of GPR55. It inhibits GPR55 signaling induced by lysophosphatidylinositol (LPI, EC50 = 1.076 µM in U2OS cells overexpressing GPR55). ML-191 inhibits LPI-induced phosphorylation of ERK1/2 (IC50 = 328 nM) and receptor-dependent translocation of PKCbetaII when used at a concentration of 30...
Keywords: | CCG-152883, CID-23612552, 5-phenyl-3-(1-(1-(p-tolyl)cyclopropane-1-carbonyl)piperidin-4-yl)-1,3,4-oxadiazol-2(3H)-one |
Application: | Forensic studies |
CAS | 931695-79-3 |
MW: | 403.5 D |
From 60.00€
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Item number: Cay15186-5
. Bloom (BLM) helicase is a DNA unwinding enzyme important for DNA repair in the homologous recombination pathway. Mutations of the BLM gene result in reduced BLM helicase activity that is associated with the rare genetic disorder, Bloom's Syndrome, and a predisposition to developing cancer. ML-216 is the first...
Keywords: | CID-49852229, N-[4-fluoro-3-(trifluoromethyl)phenyl]-N'-[5-(4-pyridinyl)-1,3,4-thiadiazol-2-yl]-urea |
Application: | BLM helicase inhibitor |
CAS | 1430213-30-1 |
MW: | 383.3 D |
From 43.00€
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Item number: Cay15189-5
ML-243 is an inhibitor of cancer stem cells, displaying 32-fold selective inhibition of a breast cancer stem cell-like cell line (EC50 = 2.0 µM) over a control (mammary epithelial) cell line (EC50 = 64 µM). It weakly antagonizes the adenosine A2A receptor (IC50 = 10 µM) and has no effect on 68 other targets commonly...
Keywords: | CID-50910523, (2E)-N-(4,5-dihydro-2-thiazolyl)-3-(4-ethylphenyl)-2-propenamide |
Application: | Cancer stem cell inhibitor |
CAS | 1426576-80-8 |
MW: | 260.4 D |
From 60.00€
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