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NADPH oxidase 1 (NOX1) generates reactive oxygen species (ROS) in colon epithelial cells that interacts with both pathogenic and normal bacteria. Excess ROS production, however, is associated with damage to the intestinal mucosa, inflammatory bowel disease, and prostate cancer. ML-090 is the first identified NOX1-specific inhibitor (IC50 = 360 nM in HEK293 cells) based on a quinoxaline scaffold that demonstrates potent selectivity over NOX2, NOX3, and NOX4 (IC50s > 10 µM) and xanthine oxidase (IC50 = 3.5 µM).Formal Name: 5,12-dihydro-quinoxalino[2,3-b]quinoxaline. CAS Number: 531-46-4. Synonyms: CCG-44699, CID-616479, Fluoflavin, NSC 179821. Molecular Formula: C14H10N4. Formula Weight: 234.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Acetonitrile: Slightly Soluble, DMF: Slightly Soluble, DMSO: Slightly Soluble, Ethanol: Slightly Soluble. lambdamax: 248, 324, 341, 393, 415, 442 nm. SMILES: C12=CC=CC=C1N=C3C(NC(C=CC=C4)=C4N3)=N2. InChi Code: InChI=1S/C14H10N4/c1-2-6-10-9(5-1)15-13-14(16-10)18-12-8-4-3-7-11(12)17-13/h1-8H,(H,15,17)(H,16,18). InChi Key: WGKYYZDYHYOKQV-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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