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NADPH oxidase 1 (NOX1) generates reactive oxygen species (ROS) in colon epithelial cells that... more
Product information "ML-090"
NADPH oxidase 1 (NOX1) generates reactive oxygen species (ROS) in colon epithelial cells that interacts with both pathogenic and normal bacteria. Excess ROS production, however, is associated with damage to the intestinal mucosa, inflammatory bowel disease, and prostate cancer. ML-090 is the first identified NOX1-specific inhibitor (IC50 = 360 nM in HEK293 cells) based on a quinoxaline scaffold that demonstrates potent selectivity over NOX2, NOX3, and NOX4 (IC50s > 10 µM) and xanthine oxidase (IC50 = 3.5 µM).Formal Name: 5,12-dihydro-quinoxalino[2,3-b]quinoxaline. CAS Number: 531-46-4. Synonyms: CCG-44699, CID-616479, Fluoflavin, NSC 179821. Molecular Formula: C14H10N4. Formula Weight: 234.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Acetonitrile: Slightly Soluble, DMF: Slightly Soluble, DMSO: Slightly Soluble, Ethanol: Slightly Soluble. lambdamax: 248, 324, 341, 393, 415, 442 nm. SMILES: C12=CC=CC=C1N=C3C(NC(C=CC=C4)=C4N3)=N2. InChi Code: InChI=1S/C14H10N4/c1-2-6-10-9(5-1)15-13-14(16-10)18-12-8-4-3-7-11(12)17-13/h1-8H,(H,15,17)(H,16,18). InChi Key: WGKYYZDYHYOKQV-UHFFFAOYSA-N.
Keywords: | CCG-44699, CID-616479, Fluoflavin, NSC 179821, 5,12-dihydro-quinoxalino[2,3-b]quinoxaline |
Supplier: | Cayman Chemical |
Supplier-Nr: | 15172 |
Properties
Application: | NADPH oxidase 1 (NOX-1) inhibitor |
MW: | 234.3 D |
Formula: | C14H10N4 |
Purity: | >95% |
Format: | Crystalline Solid |
Database Information
CAS : | 531-46-4| Matching products |
KEGG ID : | K08008 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
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H Phrases: | H302, H315, H319 |
P Phrases: | P264, P270, P280, P301+310, P302+352, P305+351+338, P321, P330, P332+313, P337+313, P362+364, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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