MK-2206 (hydrochloride)

MK-2206 (hydrochloride)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay11593-1 1 mg -

6 - 10 business days*

58.00€
Cay11593-5 5 mg -

6 - 10 business days*

114.00€
Cay11593-10 10 mg -

6 - 10 business days*

142.00€
Cay11593-25 25 mg -

6 - 10 business days*

184.00€
 
Three related forms of the kinase Akt (1, 2, 3, also known as protein kinase B isoforms PKBalpha,... more
Product information "MK-2206 (hydrochloride)"
Three related forms of the kinase Akt (1, 2, 3, also known as protein kinase B isoforms PKBalpha, beta, gamma) modulate cell proliferation, metabolism, and survival as well as angiogenesis. MK-2206 is an orally active, allosteric Akt inhibitor that is equally potent toward purified human recombinant Akt1 and Akt2 (IC50s = 5 and 12 nM, respectively) and approximately 5-fold less potent against human Akt3 (IC50 = 65 nM). In combination with other anticancer agents including topoisomerase inhibitors, antimetabolites, antimicrotubule agents, DNA cross-linkers or growth factor inhibitors, MK-2206 has been shown to synergistically inhibit cell proliferation of human cancer cell lines. At 5 µM, MK-2206 significantly enhances apoptosis in hematopoietic cells treated with chemotherapeutics.Formal Name: 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one, dihydrochloride. CAS Number: 1032350-13-2. Molecular Formula: C25H21N5O . 2HCl. Formula Weight: 480.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.2 mg/ml, DMF:PBS (pH 7.2)(1:3): 0.2 mg/ml, DMSO: 2 mg/ml. lambdamax: 210, 257, 357 nm. SMILES: NC1(CCC1)C(C=C2)=CC=C2C(C(C3=CC=CC=C3)=C4)=NC5=C4C(N6C=C5)=NNC6=O.Cl.Cl. InChi Code: InChI=1S/C25H21N5O.2ClH/c26-25(12-4-13-25)18-9-7-17(8-10-18)22-19(16-5-2-1-3-6-16)15-20-21(27-22)11-14-30-23(20)28-29-24(30)31,,/h1-3,5-11,14-15H,4,12-13,26H2,(H,29,31),2*1H. InChi Key: HWUHTJIKQZZBRA-UHFFFAOYSA-N.
Keywords: 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one, dihydrochloride
Supplier: Cayman Chemical
Supplier-Nr: 11593

Properties

Application: Allosteric Akt inhibitor
MW: 480.4 D
Formula: C25H21N5O . 2HCl
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 1032350-13-2| Matching products
KEGG ID : K04456 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302, H315, H319, H335
P Phrases: P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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