- Search results for Cay13600
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18 products were found matching "Cay13600"!
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Item number: Cay13600-50
The Aurora kinases (A, B, and C) are a family of serine-threonine kinases that regulate various stages of mitotic function. With significant roles in cell cycle and cell division, Aurora kinase gene amplification and overexpression are linked to tumorigenesis. MK-0457 is a potent pan-Aurora kinase inhibitor but...
Keywords: | Tozasertib, VX-680,... |
Application: | Aurora kinase inhibitor |
CAS | 639089-54-6 |
MW: | 464.6 D |
From 115.00€
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Item number: Cay13360-10
Isoprostanes are a family of prostanoid molecules of non-cyclooxygenase origin. 8-iso Prostaglandin E1 (8-iso PGE1) is an isoprostane which is found in human semen at levels of 7 µg/ml. It is a pulmonary vasoconstrictor in anesthetized dogs with a potency similar to PGF2alpha.Formal Name:...
Keywords: | 8-epi PGE1, 8-iso PGE1, Ovinonic acid, 9-oxo-11alpha,15S-dihydroxy-(8beta)-prost-13E-en-1-oic acid |
Application: | Bioactive lipid assays |
CAS | 21003-46-3 |
MW: | 354.5 D |
From 69.00€
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Item number: Cay13660-500
13,14-dihydro-19(R)-hydroxy Prostaglandin E1 (13,14-dihydro-19(R)-hydroxy PGE1) is the theoretical metabolite of 13,14-dihydro PGE1 (Cay-13610) by omega-1 hydroxylase. There are no known reports on its biosynthesis or biological activity.Formal Name: 9-oxo-11alpha,15S,19R-trihydroxy-prostan-1-oic acid. CAS Number:...
Keywords: | 13,14-dihydro-19(R)-hydroxy PGE1, 19(R)-hydroxy PGE0, 9-oxo-11alpha,15S,19R-trihydroxy-prostan-1-oic acid |
Application: | Bioactive lipid assays |
CAS | 2108853-39-8 |
MW: | 372.5 D |
From 143.00€
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Item number: Cay13603-50
S-Adenosyl-L-homocysteine (SAH) is an amino acid derivative and an intermediate, by-product, or modulator of several metabolic pathways, including the activated methyl cycle and cysteine biosynthesis. It is also a product of S-adenosyl-methionine (SAM)-dependent methylation of biological molecules, including DNA,...
Keywords: | AdoHcy, SAH, S-(5'-deoxyadenosin-5'-yl)-L-homocysteine |
Application: | Metabolic studies |
CAS | 979-92-0 |
MW: | 384.4 D |
From 50.00€
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Item number: Cay13601-10
The Aurora kinases have important roles in regulating mitosis and cytokinesis, with Aurora B involved in centromere function as part of the Chromosomal Passenger Complex, with survivin, INCENP, and borealin. ZM 447439 is a selective inhibitor of Aurora B kinase (IC50 = 50 nM), less potently inhibiting Aurora C and A...
Keywords: | N-[4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]-benzamide |
Application: | Aurora B kinase inhibitor |
CAS | 331771-20-1 |
MW: | 513.6 D |
From 82.00€
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Item number: Cay13602-10
MLN8237 is an inhibitor of Aurora A kinase (IC50 = 1 nM). It is selective for Aurora A over Aurora B kinase (IC50 = 396.5 nM). MLN8237 (50 nM) induces cell cycle arrest at the G2/M phase and chromosomal misalignment in HCT116 colon cancer cells. It inhibits tumor growth in a Calu-6 non-small cell lung cancer (NSCLC)...
Keywords: | Alisertib, 4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxy benzoic acid |
Application: | Aurora A kinase inhibitor |
CAS | 1028486-01-2 |
MW: | 518.9 D |
From 43.00€
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Item number: Cay13604-10
WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2. It is a much weaker inhibitor of phosphatidylinositol 3-kinase alpha (IC50 = 1,026 nM) and other kinases. WYE-354 induces G1 cell cycle arrest in both rapamycin-sensitive and...
Keywords: | 4-[6-[4-[(methoxycarbonyl)amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylic acid,... |
Application: | mTOR inhibitor |
CAS | 1062169-56-5 |
MW: | 495.5 D |
From 125.00€
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Item number: Cay13641-500
NVP-AEW541 is an inhibitor of insulin-like growth factor 1 receptor (IGF-1R, IC50 = 0.15 µM in a cell-free assay). It is selective for IGF-1R over a panel of 20 kinases but also inhibits the insulin receptor (InsR), VEGFR1, FMS-related tyrosine kinase 3 (FLT3), and tunica interna endothelial cell kinase 2 (Tie2,...
Keywords: | 7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, dihydrochloride |
Application: | IGF-1R kinase inhibitor |
CAS | 2320261-63-8 |
MW: | 512.5 D |
From 109.00€
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Item number: Cay13628-500
Salidroside is a glycoside that has been found in R. rosea and has diverse biological activities, including antioxidant, anti-apoptotic, neuroprotective, and anti-inflammatory properties. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) and ABTS (Cay-27317) radicals with EC50 values of 81.54 and 30.94...
Keywords: | Rhodioloside, 2-(4-hydroxyphenyl)ethyl-beta-D-glucopyranoside |
Application: | Apoptosis studies |
CAS | 10338-51-9 |
MW: | 300.3 D |
From 160.00€
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Item number: Cay13642-100
Alendronate is an amino bisphosphonate that inhibits farnesyl pyrophosphate (FPP) synthase (IC50 = 50 nM for the recombinant human enzyme). It inhibits bone resorption in a pit formation assay using isolated rat osteoclasts (IC50 = 2 nM). Alendronate (3 and 10 µM) reduces angiotensin II-induced collagen I synthesis...
Keywords: | Adronat, Fosamax, G-704650, MK-217, P,P'-(4-amino-1-hydroxybutylidene)bis-phosphonic acid, monosodium salt trihydrate (1:1:3) |
Application: | Bone resorption inhibitor |
CAS | 121268-17-5 |
MW: | 325.1 D |
From 38.00€
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Item number: Cay13610-500
13,14-dihydro Prostaglandin E1 (13,14-dihydro PGE1) is a biologically active metabolite of PGE1 with comparable potency to the parent compound. It is an inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 31 and 21 nM, respectively. 13,14-dihydro PGE1 is a slightly...
Keywords: | 13,14-dihydro PGE1, PGE0, 9-oxo-11alpha,15S-dihydroxy-prostan-1-oic acid |
Application: | ADP-induced platelet aggregation inhibitor |
CAS | 19313-28-1 |
MW: | 356.5 D |
From 64.00€
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Item number: Cay13627-500
Lansoprazole is a proton pump inhibitor that inhibits the H+/K+-ATPase. It inhibits K+ and H+ accumulation in gastric microsomes in a concentration-dependent manner (IC50s = 6.3 and 7.0 µM, respectively) and inhibits H+/K+-ATPase activity by approximately 60% when used at a concentration of 10 µM. Lansoprazole...
Keywords: | AG-1749, 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole |
Application: | Proton pump inhibitor |
CAS | 103577-45-3 |
MW: | 369.4 D |
From 53.00€
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