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MEG is a selective iNOS inhibitor and scavenger of peroxynitrite. The EC50 values for inhibition of iNOS (LPS-treated rat lung), eNOS (bovine endothelial), and nNOS (rat brain) are 11.5, 110, and 60 µM, respectively. MEG reacts with peroxynitrite with a second order rate constant of 1,900 M-1s-1 at 37°C. MEG has potent anti-inflammatory activity, which may be due to the combined effect of MEG acting as an inhibitor of iNOS and as a scavenger of peroxynitrite.Formal Name: (2-mercaptoethyl)-guanidine sulfate. CAS Number: 3979-00-8. Molecular Formula: [C3H9N3S]2 . H2SO4. Formula Weight: 336.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (7.2): 10 mg/ml. SMILES: N/C(N([H])CCS)=N/[H].O=S(O)(O)=O.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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