D-erythro Lysosphingomyelin (d18:1)

D-erythro Lysosphingomyelin is a bioactive sphingolipid. It is an agonist of sphingosine-1-phosphate receptor 1 (S1P1), S1P2, and S1P3 (EC50s = 167.7, 368.1, and 482.6 nM, respectively, for the human receptors). D-erythro Lysosphingomyelin is also an agonist of the orphan receptor ovarian cancer G protein-coupled receptor 1 (ORG1) that induces calcium accumulation in cells overexpressing OGR1 (EC50 = ~35 nM). Levels of D-erythro lysosphingomyelin are increased in skin isolated from patients with atopic dermatitis, as well as postmortem brain from patients with Niemann-Pick disease type A, but not type B. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1318]Formal Name: 2-[[[[2S-amino-3R-hydroxy-4E-octadecenyl]oxy]hydroxyphosphinyl]oxy]-N,N,N-trimethyl-ethanaminium. CAS Number: 1670-26-4. Synonyms: D-erythro Lyso SM(18:1), D-erythro-Sphingophosphorylcholine, D-erythro Sphingosine-1-Phosphocholine (d18:1), Lyso-SM(d18:1), Lysosphingomyelin (d18:1). Molecular Formula: C23H49N2O5P. Formula Weight: 464.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Ethanol: 15 mg/ml, PBS (pH 7.2): 5 mg/ml. SMILES: CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)COP([O-])(OCC[N+](C)(C)C)=O. InChi Code: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m0/s1. InChi Key: JLVSPVFPBBFMBE-HXSWCURESA-N.