Luotonin F

Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge, a plant used in traditional Chinese medicine for the treatment of rheumatism and various other inflammatory conditions. It demonstrates cytotoxicity against leukemia P-388 cells (IC50 = 2.3 µM) through a mechanism that involves stabilizing the DNA topoisomerase I-DNA complex.Formal Name: 2-(3-quinolinylcarbonyl)-4(3H)-quinazolinone. CAS Number: 244616-85-1. Molecular Formula: C18H11N3O2. Formula Weight: 301.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2.5 mg/ml, DMSO: 2.5 mg/ml, DMSO:PBS (pH 7.2) (1:6): 0.1 mg/ml. lambdamax: 213, 255, 304 nm. SMILES: O=C1NC(C(C2=CC(C=CC=C3)=C3N=C2)=O)=NC4=CC=CC=C41. InChi Code: InChI=1S/C18H11N3O2/c22-16(12-9-11-5-1-3-7-14(11)19-10-12)17-20-15-8-4-2-6-13(15)18(23)21-17/h1-10H,(H,20,21,23). InChi Key: HSEIGGKZBVNIDH-UHFFFAOYSA-N.