Loratadine

Loratadine
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay15625-5 5 mg -

6 - 10 business days*

60.00€
Cay15625-10 10 mg -

6 - 10 business days*

105.00€
Cay15625-25 25 mg -

6 - 10 business days*

175.00€
Cay15625-50 50 mg -

6 - 10 business days*

259.00€
 
Loratadine is a non-sedating antihistamine that acts as a selective inverse agonist of peripheral... more
Product information "Loratadine"
Loratadine is a non-sedating antihistamine that acts as a selective inverse agonist of peripheral histamine H1 receptors (Ki = 35 nM). It has been shown to inhibit the release of leukotriene C4 (IC50 = 8 µM) and histamine (IC50 = 11 µM) from rodent mast cells and to inhibit allergic bronchospasm in guinea pigs with an ED50 value of 0.40 mg/kg. Formulations containing loratadine have been used in the treatment of allergic rhinitis and chronic idiopathic urticaria.Formal Name: 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid, ethyl ester. CAS Number: 79794-75-5. Synonyms: SCH 29851. Molecular Formula: C22H23ClN2O2. Formula Weight: 382.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 25 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 247 nm. SMILES: ClC(C=C1)=CC(CCC2=C/3N=CC=C2)=C1C3=C4CCN(C(OCC)=O)CC/4. InChi Code: InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3. InChi Key: JCCNYMKQOSZNPW-UHFFFAOYSA-N.
Keywords: SCH 29851, 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid, ethyl ester
Supplier: Cayman Chemical
Supplier-Nr: 15625

Properties

Application: Histamine H1 receptor antagonist
MW: 382.9 D
Formula: C22H23ClN2O2
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 79794-75-5| Matching products
KEGG ID : K04149 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319, H335
P Phrases: P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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