18 products were found matching "702"!

Bodi Fluor 488 amine is an excellent building block for developing fluorescent probes. Bodi Fluor 488 is the same fluorophore as BODIPY FL (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene FL). It is a popular lipophilic fluorescent dye molecule used in biology, chemistry, and materials science. BODI Fluor 488 has high...

Protein produced in genetically engineered yeast cells as a fusion protein with human superoxide dismutase (SOD). It covers from Asp 166 to Arg 440 (D Ala 313 to Ala 331) of the HTLV-I envelope protein (isolate ATK-1). Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, aliquot...

Applications: , Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilutions: ELISA: 1:100-1:1000, Western Blot: 1:100-1:1000, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing...

VX-702 is a second-generation, orally active mitogen-activated protein kinase (MAPK) p38 inhibitor. It is being tested for the potential treatment of inflammation, rheumatoid arthritis and cardiovascular diseases. Solubility: Soluble in DMSO. Storage and Stability: May be stored at RT for short-term only. Long-term...

VX-702 is a third generation inhibitor of p38 mitogen-activated protein (MAP) kinases, binding to both p38alpha and p38beta (Kd = 3.7 and 17 nM, respectively) in an ATP-competitive fashion. It inhibits IL-6, IL-1beta, and TNF-alpha production in LPS-primed blood with IC50 values of 59, 122, and 99 ng/ml,...

VX-702 inhibits p38 MAPK, preventing p38 MAPK-dependent inflammatory cytokine release. VX-702 is in development to treat inflammation and cardiovascular diseases and currently shows mixed results in clinical trials as a potential treatment for rheumatoid arthritis. In vitro, VX-702 decreases platelet lesioning in...

Soluble in DMSO or ethanol. The kinases called p38 MAP kinases (MAPKs) are intracellular, soluble serine-threonine kinases which belong to a large family of proteins that include the extracellular regulated kinases (ERKs) and c-Jun N-terminal kinases (JNKs). So far four p38 isoforms have been identified, namely...

Format - F(ab')2

Format - F(ab')2, affinity purified

Format - F(ab')2, affinity purified

Format - F(ab')2, affinity purified

Format - F(ab')2, affinity purified