- Search results for Cay14860
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7 products were found matching "Cay14860"!
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Item number: Cay14860-25
Leflunomide is a synthetic isoxazol and a prodrug form of A-771726 (Cay-14404), a dihydroorotate dehydrogenase inhibitor. Leflunomide inhibits de novo pyrimidine synthesis to regulate T lymphocyte progression through the cell cycle. It inhibits proliferation and activation of T cells when used at concentrations of...
Keywords: | Arava, HW 486, SU 101, 5-methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide |
Application: | Immunosuppressant, Pyrimidine synthesis inhibitor, Dihydroorotate dehydrogenase inhibitor |
CAS | 75706-12-6 |
MW: | 270.2 D |
From 43.00€
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Item number: Cay14863-10
Akt functions as a key component in multiple signaling pathways to promote cell survival by mediating resistance to apoptosis. Akt inhibitor X is a cell permeable phenoxazine derivative that suppresses insulin-like growth factor 1 (IGF-1)-stimulated phosphorylation of Akt with an IC50 value of 1-2 µM. This compound...
Keywords: | 10-DEBC, 2-chloro-N,N-diethyl-10H-phenoxazine-10-butanamine, monohydrochloride |
Application: | Akt phosphorylation inhibitor |
CAS | 925681-41-0 |
MW: | 381.3 D |
From 66.00€
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Item number: Cay14868-10
Vatalanib is an antagonist of the VEGF receptors, inhibiting the receptor tyrosine kinase activities of VEGFR1 (Flt1), VEGFR2 (KDR), and VEGFR3 (Flt4) with IC50 values of 77, 37, and 190 nM, respectively. It less potently inhibits PDGF and c-Kit (IC50 = 600 and 700 nM) and has no effect on a large panel of...
Keywords: | CGP 79787, PTK/ZK, PTK787, N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine, dihydrochloride |
Application: | VEGFR inhibitor |
CAS | 212141-51-0 |
MW: | 419.7 D |
From 69.00€
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Item number: Cay14867-10
Aprepitant an antiemetic and antagonist of the neurokinin-1 (NK1) receptor (Ki = 3 nM, IC50 = 0.09 nM for the human receptor). It is selective for NK1 over NK3 receptors (Ki = 454.1 nM for human NK3). In vivo, aprepitant (1 mg/kg) prevents plasma extravasation into the esophagus of guinea pigs induced by substance P...
Keywords: | Emend, L-754,030, MK-869, ONO-7436,... |
Application: | NK-1 receptor antagonist |
CAS | 170729-80-3 |
MW: | 534.4 D |
From 50.00€
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Item number: Cay14869-10
Marimastat is a broad-spectrum matrix metalloproteinase (MMP) inhibitor (IC50s = 5, 6, 230, 16, and 3 nM for MMP-1, MMP-2, MMP-3, MMP-7, and MMP-9, respectively). It also binds to a recombinantly expressed catalytic domain of human MMP-14 (MMP-14cat, Ki = 2.1 nM) and inhibits gelatinases (IC50s = 3-6 nM), fibroblast...
Keywords: | BB-2516, KB-R8898,... |
Application: | MMP inhibitor |
CAS | 154039-60-8 |
MW: | 331.4 D |
From 60.00€
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Item number: Cay14865-50
alpha-Truxillic acid can be formed by the dimerization of two molecules of alpha-trans-cinnamic acid. It is related to incarvillateine, a natural antinociceptive compound derived from the Asian herb I. sinensis. alpha-Truxillic acid and some of its derivatives significantly block inflammatory pain while having...
Keywords: | Gratissimic Acid, (1alpha,2alpha,3beta,4beta)-2,4-diphenyl-1,3-cyclobutanedicarboxylic acid |
Application: | Antinociceptive compound |
CAS | 490-20-0 |
MW: | 296.3 D |
From 43.00€
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Item number: Cay14866-10
Silodosin is a potent alpha1A-adrenoceptor antagonist (Ki = 0.036 nM). It shows selectivity for the prostatic adrenoceptor. As a result, it is effective against lower urinary tract symptoms associated with benign prostatic hyperplasia.Formal Name:...
Keywords: | KMD-3213,... |
Application: | alpha 1A adrenoceptor antagonist |
CAS | 160970-54-7 |
MW: | 495.5 D |
From 66.00€
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