LY364947

LY364947
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13341-5 5 mg -

6 - 10 business days*

123.00€
Cay13341-10 10 mg -

6 - 10 business days*

233.00€
Cay13341-25 25 mg -

6 - 10 business days*

541.00€
Cay13341-50 50 mg -

6 - 10 business days*

963.00€
 
Transforming growth factor-beta (TGF-beta) signals through a cell surface heteromeric complex... more
Product information "LY364947"
Transforming growth factor-beta (TGF-beta) signals through a cell surface heteromeric complex involving type I (TGF-beta RI) and type II (TGF-beta RII) receptors. Downstream signal transduction is mediated by the TGF-beta RI kinase domain through the phosphorylation of Smad proteins. LY364947 is a selective inhibitor of TGF-beta RI (TGFR-I, TbetaR-I, ALK-5), with an IC50 value of 59 nM. LY364947 less effectively inhibits TGF-beta RII (IC50 = 400 nM), p38 MAPK (IC50 = 740 nM), and mixed-lineage kinase 7 (MLK7, IC50 = 1,400 nM). It inhibits TGF-beta-induced cell growth (IC50 = 89 nM) in NIH 3T3 mouse fibroblasts and TGF-beta-directed Smad phosphorylation, synthesis of fibronectin, PAI-1 and uPA protein, and matrigel invasion in MDA-MB-231 cells.Formal Name: 4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-quinoline. CAS Number: 396129-53-6. Synonyms: HTS 466284, TGF-beta RI Kinase Inhibitor. Molecular Formula: C17H12N4. Formula Weight: 272.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 1 mg/ml. lambdamax: 229, 283 nm. SMILES: C1(C2=CC=NC3=C2C=CC=C3)=CNN=C1C4=NC=CC=C4. InChi Code: InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21). InChi Key: IBCXZJCWDGCXQT-UHFFFAOYSA-N.
Keywords: HTS 466284, TGF-beta RI Kinase Inhibitor, 4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-quinoline
Supplier: Cayman Chemical
Supplier-Nr: 13341

Properties

Application: TGFbetaRI inhibitor
MW: 272.3 D
Formula: C17H12N4
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 396129-53-6| Matching products
KEGG ID : K04674 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H301, H315, H319, H335, H400
P Phrases: P261, P264, P270, P271, P273, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P391, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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