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LTbetaR -muIg Fusion Protein, (human), preservative free

ART NR.: ANC-536-820 (25 µg)

Hersteller: Ancell

Datenblatt



MSDS

Anwendungen: ELISA

MW: 48 kD

Format: affinity purified

UniProt ID: P36941
Suche mit UniProt ID

Geninformationen: GeneID 4055

Schlagworte: LTBR, D12S370, TNF-RIII, TNFR-III, Lymphotoxin-beta receptor, Tumor necrosis factor C receptor, Tumor necrosis factor receptor type III, Tumor necrosis factor receptor 2-related protein, Tumor necrosis factor receptor superfamily member 3

ANC-536-820

25 µg

422 €

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Bemerkungen: The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines, and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.

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