LTbetaR (human):Fc (human) (rec.) (non-lytic)

LTbetaR (human):Fc (human) (rec.) (non-lytic)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
CHI-HF-220LTBR-C100 100 µg - -

3 - 9 business days*

418.00€
 
The extracellular domain of human LTbetaR (aa 31-225) is fused at the C-terminus to the Fc... more
Product information "LTbetaR (human):Fc (human) (rec.) (non-lytic)"
The extracellular domain of human LTbetaR (aa 31-225) is fused at the C-terminus to the Fc portion of a mutant human IgG1. Lyophilized from 0.2µm-filtered solution in PBS. Shows the biological function of the LTbetaR moiety and exerts a prolonged circulating half-life caused by the modified Fc domain. The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines, and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.
Keywords: LTBR, D12S370, TNF-RIII, TNFR-III, Lymphotoxin-beta receptor, Tumor necrosis factor C receptor, Tumor necrosis factor receptor type III, Tumor necrosis factor receptor 2-related protein, Tumor necrosis factor receptor superfamily member 3
Supplier: Chimerigen Laboratories
Supplier-Nr: HF-220LTBR

Properties

Application: Bioassays
Conjugate: No
Host: Hamster cells
Species reactivity: human
Purity: >98%
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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