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LTbetaR (human):Fc (human) (rec.) (non-lytic)

ART NR.: CHI-HF-220LTBR-C100 (100 µg)

Hersteller: Chimerigen


Anwendungen: Bioassays

Reinheit: >98%

Format: lyophilized

UniProt ID: P36941
Suche mit UniProt ID

Geninformationen: GeneID 4055

Schlagworte: LTBR, D12S370, TNF-RIII, TNFR-III, Lymphotoxin-beta receptor, Tumor necrosis factor C receptor, Tumor necrosis factor receptor type III, Tumor necrosis factor receptor 2-related protein, Tumor necrosis factor receptor superfamily member 3

100 µg

352 €

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Bemerkungen: The extracellular domain of human LTbetaR (aa 31-225) is fused at the C-terminus to the Fc portion of a mutant human IgG1. Lyophilized from 0.2µm-filtered solution in PBS. Shows the biological function of the LTbetaR moiety and exerts a prolonged circulating half-life caused by the modified Fc domain. The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines, and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.

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