15 products were found matching "Cay80210-10"!

L-NMMA is a relatively non-selective inhibitor of all NOS isoforms. It is the archetypal NOS inhibitor to which other inhibitors are most often compared. The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 µM, respectively.Formal Name:...

NG,NG-dimethyl-L-arginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS). It is formed from arginine by protein arginine methyltransferases (PRMTs) and degraded by dimethylarginine dimethylaminohydrolases (DDAHs) and alanine-glyoxylate aminotransferase 2 (AGXT2). ADMA levels are increased...

Thioarginine is a colorimetric substrate for arginase. Arginase binds to and hydrolyzes thioarginine to release 2-amino-5-mercaptovaleric acid, which reacts with DTNB (Ellman's reagent) to form 2-nitro-5-thiobenzoate and can be quantified by colorimetric detection at 412 nm as a measure of arginase activity.Formal...

L-NNA is a competitive inhibitor of nitric oxide synthase (NOS) with selectivity for the neuronal and endothelial isoforms of the enzyme. Although L-NAME is much more soluble than L-NNA in aqueous systems, a hydrolysis step is required to "activate" L-NAME, thus adding complexity to an in vivo experiment. L-NNA...

1-Octacosanol is a very long-chain fatty alcohol that has diverse biological activities, including antibacterial, antifungal, anti-inflammatory, and antioxidative properties. It is active against the bacteria K. pneumoniae, S. flexneri, S. typhi, and E. faecalis (MICs = 4, 8, 2, and 32 µg/ml, respectively), as well...

Leukotriene A4 (LTA4) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase (5-LO), which exhibits both lipoxygenase and LTA4 synthase activities. LTA4 is rapidly metabolized by LTA4 hydrolase or LTC4 synthase to LTB4 or LTC4, respectively. LTA4, from leukocytes, is known...

AMT is a potent, relatively selective inhibitor of iNOS with a Ki of 4.2 nM in mouse macrophages. It inhibits other isoforms of NOS, but at higher concentrations, the IC50 values for rat nNOS and bovine eNOS are 34 and 150 nM, respectively.Formal Name: 5,6-dihydro-6-methyl-4H-1,3-thiazin-2-amine, hydrochloride. CAS...

Carbaprostacyclin is a stable analog of PGI2. When infused in rabbits or dogs, it inhibits ex vivo platelet aggregation, but the effect persists only 10 minutes after termination of the infusion. This implies rapid metabolic inactivation of carbaprostacyclin. Carbaprostacyclin inhibits platelet aggregation with 10%...

Anthrax edema factor (EF) is a component of edema toxin (EdTx) produced by B. anthracis. It is comprised of an N-terminal protective antigen (PA) binding domain (PABD), an adenylyl cyclase domain, and a helical domain. Inactive EF binds oligomerized B. anthracis PA on the host cell surface. EF and PA, together known...

MEG is a selective iNOS inhibitor and scavenger of peroxynitrite. The EC50 values for inhibition of iNOS (LPS-treated rat lung), eNOS (bovine endothelial), and nNOS (rat brain) are 11.5, 110, and 60 µM, respectively. MEG reacts with peroxynitrite with a second order rate constant of 1,900 M-1s-1 at 37°C. MEG has...

CCG-50014 is an inhibitor of regulator of G protein signaling 4 (RGS4) (IC50 = 30 nM) and is > 20-fold selective for RGS4 over other RGS proteins. RGS proteins bind to the Galpha subunits of activated heterotrimeric G proteins and accelerate the rate of GTP hydrolysis, acting as GTPase-activating proteins. CCG-50014...

MM-11253 is a synthetic, conformationally restricted retinoid that acts as a selective antagonist of retinoic acid receptor gamma (RARgamma). It dose-dependently blocks the ability of RARgamma-selective agonists, but not retinoic acid (all-trans retinoic acid, Cay-11017), to inhibit the growth of oral squamous cell...