- Search results for Cay80210-1
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32 products were found matching "Cay80210-1"!
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Item number: Cay10210-1
Prostaglandin A2 (PGA2) is a naturally occurring prostaglandin in gorgonian corals where it may function in self defense. It is generally not present in mammals. PGA2 has low biological potency in most bioassays, but it does show some antiviral/antitumor activity. At a 25 µM concentration, PGA2 blocks the cell cycle...
Keywords: | Medullin, PGA2, 9-oxo-15S-hydroxy-prosta-5Z,10,13E-trien-1-oic acid |
Application: | Bioactive lipid assays |
CAS | 13345-50-1 |
MW: | 334.5 D |
From 43.00€
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Item number: Cay81020-10
MEG is a selective iNOS inhibitor and scavenger of peroxynitrite. The EC50 values for inhibition of iNOS (LPS-treated rat lung), eNOS (bovine endothelial), and nNOS (rat brain) are 11.5, 110, and 60 µM, respectively. MEG reacts with peroxynitrite with a second order rate constant of 1,900 M-1s-1 at 37°C. MEG has...
Keywords: | (2-mercaptoethyl)-guanidine sulfate |
Application: | iNOS inhibitor |
CAS | 3979-00-8 |
MW: | 336.4 D |
From 92.00€
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Item number: Cay82100-10
DEA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 2 minutes and 16 minutes at 37°C and 22-25°C, pH 7.4, respectively, to liberate 1.5 moles of NO per mole of parent compound.Formal Name: Diethylammonium (Z)-1-(N,N-diethylamino)diazen-1-ium-1,2-diolate....
Keywords: | DEA/NO, Diethylamine NONOate, Diethylammonium (Z)-1-(N,N-diethylamino)diazen-1-ium-1,2-diolate |
Application: | NO donor |
CAS | 372965-00-9 |
MW: | 206.3 D |
From 34.00€
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Item number: Cay10802-10
CCG-50014 is an inhibitor of regulator of G protein signaling 4 (RGS4) (IC50 = 30 nM) and is > 20-fold selective for RGS4 over other RGS proteins. RGS proteins bind to the Galpha subunits of activated heterotrimeric G proteins and accelerate the rate of GTP hydrolysis, acting as GTPase-activating proteins. CCG-50014...
Keywords: | 4-[(4-fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione |
Application: | RGS4 inhibitor |
CAS | 883050-24-6 |
MW: | 316.3 D |
From 36.00€
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Item number: Cay19802-10
S 2101 is an inhibitor of lysine-specific demethylase 1 (LSD1, Ki = 0.61 µM). It is selective for LSD1 over monoamine oxidase A (MAO-A) and MAO-B (Kis = 17 and 110 µM, respectively).Formal Name: (1R,2S)-rel-2-[3,5-difluoro-2-(phenylmethoxy)phenyl]-cyclopropanamine, monohydrochloride. CAS Number: 1239262-36-2....
Keywords: | KDM1 inhibitor II, LSD1 inhibitor II, Lysine-specific Demethylase 1 Inhibitor II,... |
Application: | LSD1 inhibitor |
CAS | 1239262-36-2 |
MW: | 311.8 D |
From 50.00€
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Item number: Cay11802-10
Normal development and tissue repair are controlled in part by SMADs, a family of intracellular proteins that are activated by signaling via serine/threonine kinase receptors of the TGF-beta superfamily. LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are...
Keywords: | 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline |
Application: | BMP type I receptor inhibitor |
CAS | 1062368-24-4 |
MW: | 406.5 D |
From 44.00€
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Item number: Cay16802-10
CFSE is a fluorescent product of CFDA-SE (Cay-14456) cleavage by intracellular esterases. CFSE lacks the diacetate groups of CFDA-SE and, as a result, is less cell permeable. CFSE fluorescence is cytoplasmic, and it has excitation/emission maxima of 491 and 518 nm, respectively. It covalently couples to...
Keywords: | 5-Carboxyfluorescein NHS ester, 5-Carboxyfluorescein N-Succinimidyl ester, 5-Carboxyfluorescein-N-hydroxysuccinimide... |
Application: | Cell-permeable green fluorescent dye, Cell labeling |
CAS | 92557-80-7 |
MW: | 473.4 D |
From 121.00€
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Item number: Cay17802-10
Cevimeline is a muscarinic receptor agonist (EC50s = 23, 48, and 63 nM for M1, M3, and M5, respectively, and >1 µM for M2 and M4). It stimulates secretion by salivary glands and is useful in ameliorating xerostomia (dry mouth).Formal Name:...
Keywords: | AF 102B, SNI 2011, SNK 508, (2'R,3R)-rel-2'-methyl-spiro[1-azabicyclo[2.2.2]octane-3,5'-[1,3]oxathiolane], monohydrochloride |
Application: | Muscarinic receptor agonist |
CAS | 107220-28-0 |
MW: | 235.8 D |
From 50.00€
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Item number: Cay14802-10
Bryostatin 1 is a marine macrolide that has been found in B. neritina and has diverse biological activities.,,,, It binds to PKCalpha, PKCbeta1, PKCgamma, PKCdelta, PKCepsilon, PKCeta, and PKCtheta (Kis = 0.8-3.0 nM) and induces PKC activation or inhibition in cancer cells in a concentration-dependent manner.,...
Keywords: | NSC 339555,... |
Application: | Bioactive marine macrolide, PKC modulator |
CAS | 83314-01-6 |
MW: | 905 D |
320.00€
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Item number: Cay80220-1
L-NNA is a competitive inhibitor of nitric oxide synthase (NOS) with selectivity for the neuronal and endothelial isoforms of the enzyme. Although L-NAME is much more soluble than L-NNA in aqueous systems, a hydrolysis step is required to "activate" L-NAME, thus adding complexity to an in vivo experiment. L-NNA...
Keywords: | L-NG-Nitroarginine, NG-nitro-L-Arginine, N5-[imino(nitroamino)methyl]-L-ornithine |
Application: | NOS inhibitor |
CAS | 2149-70-4 |
MW: | 219.2 D |
From 20.00€
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Item number: Cay40210-1
TNF-beta, also known as lymphotoxin-alpha (LT-alpha), is a cytokine and member of the TNF and TNF receptor (TNFR) cytokine superfamily. It is produced as an N-glycosylated peptide that forms soluble bell-shaped homotrimers after signal peptide cleavage. TNF-beta also forms cell surface-anchored heterotrimers with...
Keywords: | LTA, TNFB, LT-alpha, TNF-beta, LT-alpha, TNF-beta, Lymphotoxin-alpha, Lymphotoxin-alpha, Tumor necrosis factor ligand... |
Application: | Active |
From 467.00€
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Item number: Cay20872-10
MY-5445 is a selective inhibitor of the cyclic GMP (cGMP) phosphodiesterase, PDE5, with a Ki value of 1.3 µM. It inhibits calcium- and cAMP-selective PDEs with Ki values of >1,000 and 915 µM, respectively. MY-5445 has been shown to relax intact strips of rat aorta with an EC50 value of 4 µM.Formal Name:...
Keywords: | N-(3-chlorophenyl)-4-phenyl-1-phthalazinamine |
Application: | PDE5 inhibitor |
CAS | 78351-75-4 |
MW: | 331.8 D |
From 43.00€
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