- Search results for Cay15215
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11 products were found matching "Cay15215"!
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Item number: Cay15215-5
Breast cancer resistance protein (BCRP) is an ATP-binding cassette protein known also as ABCG2. While it normally functions as a high-capacity urate exporter in the renal system, it also acts as a xenobiotic transporter and contributes to multidrug resistance (e.g., to mitoxantrone) in certain types of cancer. BCRP...
Keywords: | (3S,6S,12aS)-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxo-pyrazino[1',2':1,6]pyrido[3,4-b]indole-3-... |
Application: | ABCG2 inhibitor |
CAS | 461054-93-3 |
MW: | 469.6 D |
From 161.00€
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Item number: Cay15521-5
Lorcaserin (hydrochloride) (Cay-15521) is an analytical reference material categorized as an anorectic. It also decreases oxycodone intake and has positive effects on self-administration and relapse vulnerability in the rat. Lorcaserin is regulated as a Schedule IV compound in the United States. This product is...
Keywords: | APD356, 8-chloro-2,3,4,5-tetrahydro-1R-methyl-1H-3-benzazepine, monohydrochloride |
Application: | Analytical reference material, Anorectic, 5-HT2C-receptor agonist |
CAS | 846589-98-8 |
MW: | 232.2 D |
From 43.00€
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Item number: Cay15221-5
HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50 = 1.5 µM) without significantly affecting Wnt signaling (IC50 > 30 µM). HPI-1 suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational...
Keywords: | 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylic acid-2-methoxyethyl... |
Application: | Hedgehog pathway inhibitor |
MW: | 463.5 D |
From 142.00€
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Item number: Cay15211-5
Shz-1 is a Shz that activates cardiac differentiation, inducing the expression of early cardiac genes in mouse pluripotent and embryonic stem cells in vitro at low micromolar concentrations. In addition, Shz-1 drives differentiation of human peripheral blood mononuclear cells, mobilized by granule colony-stimulating...
Keywords: | Sulfonylhydrazone-1, benzenesulfonic acid, 2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide |
Application: | Cardiac gene expression inducer |
CAS | 326886-05-9 |
MW: | 355.2 D |
From 84.00€
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Item number: Cay15216-5
Conduritol B epoxide (CBE) is an irreversible inhibitor of glucocerebrosidase, also known as acid beta-glucosidase, glucosylceramidase, GBA, or GBA1 (IC50 = 9 µM). Inhibition of this lysosomal glucosidase results in the accumulation of glucocerebroside without affecting cell viability, lysosomal enzyme release, or...
Keywords: | CBE, 1,2-anhydro-myo-inositol |
Application: | Irreversible glucocerebrosidase inhibitor |
CAS | 6090-95-5 |
MW: | 162.1 D |
From 73.00€
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Item number: Cay15219-5
PPARbeta/delta is thought to play a role in lipid homeostasis and glucose disposal by regulating genes involved in fatty acid oxidation, reverse cholesterol transport, and carbon substrate utilization in skeletal muscle. It has also been implicated in the progression of certain cancers. GSK3787 is an irreversible...
Keywords: | 4-chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]-benzamide |
Application: | PPARbeta/delta antagonist |
CAS | 188591-46-0 |
MW: | 392.8 D |
From 64.00€
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Item number: Cay15217-5
NEDD8 is an ubiquitin-like protein whose activity is required to activate cullin-RING ubiquitin E3 ligases (CRLs) responsible for the ubiquitination and proteasome-dependent turnover of certain substrates with roles relevant to cellular processes important for cancer cell survival. Neddylation of CRLs is initiated...
Keywords: | Pevonedistat, sulfamic acid,... |
Application: | Adenosine 5'-monophosphate analog, NAE inhibitor |
CAS | 905579-51-3 |
MW: | 443.5 D |
From 66.00€
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Item number: Cay15214-5
Epalrestat is an inhibitor of aldose reductase (IC50s = 0.01 and 0.26 µM for rat lens and human placenta aldose reductase, respectively). It inhibits glucose-induced sorbitol accumulation in isolated rat lens, rat sciatic nerve, and human erythrocytes (IC50s = 1.5, 5, and 1.5 µM, respectively). It decreases high...
Keywords: | ONO-2235, 5Z-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid |
Application: | Aldose reductase inhibitor |
CAS | 82159-09-9 |
MW: | 319.4 D |
From 98.00€
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Item number: Cay15210-5
6-keto Prostaglandin F1alpha (6-keto PGF1alpha) is the inactive, non-enzymatic hydrolysis product of PGI2. 6-keto PGF1alpha serves as a useful marker of PGI2 biosynthesis in vivo. When [3H]-PGI2 is injected into healthy human males, 6.6% of the radioactivity is recovered from urine as [3H]-6-keto PGF1alpha.Formal...
Keywords: | 6-keto PGF1alpha, 6-oxo-9alpha,11alpha,15S-trihydroxy-prost-13E-en-1-oic acid |
Application: | Bioactive lipid assays |
CAS | 58962-34-8 |
MW: | 370.5 D |
From 130.00€
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Item number: Cay15212-5
Ketoconazole is a broad-spectrum triazole antifungal agent that has activity against C. albicans, C. krusei, C. tropicalis, C. glabrata, C. parapsilosis, C. neoformans, and A. fumigatus strains (IC50s = 0.031-8 µg/ml). It inhibits the fungal cytochrome P450 (CYP) isoform CYP51, also known as lanosterol...
Keywords: | R 41400,... |
Application: | Cytochrome P450 inhibitor |
CAS | 65277-42-1 |
MW: | 531.4 D |
From 77.00€
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Item number: Cay15213-5
Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents. It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 µM. In addition, amiodarone binds with high affinity to the sigma-1...
Keywords: | (2-butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]-methanone, monohydrochloride |
Application: | Ion channel blocker |
CAS | 19774-82-4 |
MW: | 681.8 D |
From 43.00€
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